Derek (More Plates More Dates)

Cognitive health, some level of cardiovascular support, bone integrity, anabolic activity in muscle tissue, all of the same stuff is still the case in women, just to a...

much lower magnitude so but similar as you would expect there's less of a concentration required to sustain a female musculature than a male so the concentration differential is about 10x but in women the main function of testosterone still overlaps with males but intragonadally it is more to facilitate as a substrate of estrogen production so getting that sufficient amount of aromatization into

estradiol, but also the conversion into estrone, which then turns into estradiol as well to facilitate all of the female fertility facilitated processes.

I think it would be highly speculative because obviously I would love to just point to some clear-cut literature that says based on these studies on, you know, inhibiting IGF-1 or having really low androgen levels equals lower body weights equals longer lifespan or something to that effect that could be a common kind of denominator, but it's not as cut and dry.

I do think there is some level of metabolic activity

resource demand that is needed to actually support the infrastructure of a male that is more intensive than a female.

So I would, in general, like larger humans are going to die quicker than smaller ones, at least from what I've seen trend wise.

And

in supporting that it is something that requires more hormone production in general, which is also more intensive on all organ systems accordingly to actually facilitate and get that hormone production to the level it needs to sustain that larger human.

So that's a highly speculative take on it, but that would be part of the reason.

But at a high level, if you want to extrapolate to

You know, at higher levels, androgens will be neurotoxic in a dose dependent manner past supra levels.

It will cause cardiac remodeling in a negative manner, like all of the dyslipidemia, all of the negatives that you would hear about when it comes to anabolic steroid use.

to some extent at supra levels are going to be present from testosterone all but to a more muted extent because it's not a synthetic drug that is manipulated in a lab to create you know something that is not a substrate for aromatization and some of the other stuff that is protective but that's a high level speculative take

The like the male castrati, like so the men that are like, yeah, they castrate like they are osteoporotic as a consequence of a lack of sufficient aromatization into estrogen.

and their growth plates, the epiphyseal growth plates don't close fully because of that lack of aromatization in adolescence, which is facilitated essentially entirely by testosterone as a substrate, similar to what it is in women.

But if you castrate a male in adolescence and he no longer has intratesticular testosterone production, he is now functioning off of solely adrenal production, which is like a drop in the bucket to what you actually need to function at a high level.

Like you're not going to have

sufficient bone development and you are going to suffer from osteoporosis inevitably.

And if those those who don't know what the castrati are, it's really interesting.