Derek (More Plates More Dates)

It's kind of a crazy thing how in this day and age we have like advanced AI stuff.

We have like all these like cutting edge treatments for you can like literally completely get rid of the likelihood of ASCVDs or crushing ApoB and like different things of this nature.

But like hair loss, no one has a fucking clue what happens or how to prevent it without just crushing your DHT levels, essentially, which is wild that that's still a thing.

But yeah.

As long as I've been researching this stuff, there's been people that are like, oh, the, you know, the solutions on the horizon, like every two weeks you'll see some viral article on Twitter.

UCLA scientists found like Rodin regroup all his hair after shaved from like random thing.

Like, oh my God, D-ribose is the solution.

I'm going to go dump it on my head.

You should see the nutty shit that people on like Reddit and whatnot dump on their heads.

Yeah, I think sulforaphane was one too at one point.

Didn't end up working though.

I'm sure it has some indirect benefit for systemic health, but at the end of the day, the unfortunate reality, inherently in the name of what it is, is what is causing it, which is androgenic, androgen-mediated alopecia.

So the miniaturization of hair follicles mediated by androgens, primarily the one that is the most potent in its androgenic activity, which is DHT,

And these hormones, it's not just like they convert and then have like in the blood or like at the liver or something, there is like tissue specific concentrations of enzymes that are more prominent.

And in particular in the skin, in the scalp especially too, you will have, there's way more 5-alpha reductase density in men for converting testosterone to DHT.

So that like local reaction where you're converting more testosterone

into DHT is resulting in like a significantly high per surface area amount of DHT than like any almost any other area in the body with exception of like

like other skin areas that are hairy, you know, the prostate as well, like the scrotum when you apply the cream, like you actually get a bit of a disproportionate spike in DHT I mentioned earlier.

But anyway, and the scalp, highly expressing 5-alpha reductase, and that conversion seems to be what mediates androgenic alopecia in men.

Essentially all cases.