Dr. Alyssa Olenick
speaker
1,412 appearances
1 recordings
1 series
first heard Jul 2026
last heard 7 Jul
Dr. Alyssa Olenick’s voice in public audio — every appearance, attributed to the second.
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is unique to resistance training.
Then you have endurance training.
And this cascade is essentially turned on by energy deficits in your cell.
Essentially, you start doing activity, there's turnover of glucose, ATP, all of our energy systems fuel and sense that deficit.
And that deficit in energy inside of our cells turns on a different pathway.
And it turns on some of these things called.
Um, PGCO and alpha, which is really important for simulation of mitochondrial biogenesis and all these other positive adaptations of aerobic training, but it also turns on something called AMPK.
And AMPK essentially is like the neighbor kid messenger that goes and then locks the door to the house.
So you can't get in to the resistance training house, essentially, if you want to play on the kids in house craziness.
And essentially that when AMPK is really upregulated, there's kind of this like blocking of that protein synthesis pathway.
Now which would be mTOR.
Yeah, which would be mTOR.
Now, is the degree of what's that happening 100% every time it happens?
No, I think that it's you can think of it almost like
like muscle stimulus soup.
Like there's so many other things that are also happening.
Um, but there is a down regulation because you have to think muscle is a pathway where your body is taking
you know, proteins and building and it's it's anabolic.
You're trying to build tissue.
Where endurance training by nature is catabolic in the sense of it's breaking down fats, carbs, hopefully not proteins, but sometimes for energy metabolism, because in the moment it's trying just to supply supply the output.
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