Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
So just getting those... Raw spinach or cooked spinach?
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
I think... I actually... I don't think it actually... It might have said in the methods, but...
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
I would imagine raw because you want to get those undenatured thylakoids in the gut.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
So just kind of another... Actually, thylakoids do a lot of other interesting stuff.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
They inhibit lipase in the gut and so actually help more fat get down to the distal small bowel and promote satiety.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
So this is one of the reasons why you talk about, oh, the people who eat all these healthy foods and greens, they're less hungry.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
It's like it's biochemistry.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
Like there's stuff happening in there that is making...
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
the hunger signals go down through things like inhibiting lipase, improving GLP-1 secretion.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
So other things for GLP-1 secretion, the thylakoids, also fiber has been shown, specific amino acids, so high-protein foods, things that involve a lot of valine and glutamine, green tea, and specifically the ECGC that is one of the compounds in green tea, that's been shown to stimulate GLP-1 secretion.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
curcumin.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
Um, so there's several things that are all in that like whole food, you know, basically things you would associate with a healthy diet, but we actually know they stimulate GLP-1.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
So I, you know, those are all things I try to include in my diet.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
And the last one is inhibition of DPP-4.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
And that one, there's just actually, when you look at the research, there's some kind of
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
black beans, Mexican oregano, other forms of oregano, rosemary, guava, and I wrote this one down because it's a word I hadn't seen very much before I started digging into this, but myricitin, which is found in berries, cranberries, and peppers, and Swiss chard.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
So all that is to say, ultimately, many of us are gripped by cravings.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
And the idea of
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
just sort of not being constantly driven to eat more, which I would argue that about 80% of Americans are, feels really hard to overcome.
Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
But a lot of it is literally just communicating to yourselves in a clear way through food,