Dr. Craig Koniver
speaker
302 appearances
1 recordings
1 series
first heard Oct 2024
last heard Oct 2024
Dr. Craig Koniver’s voice in public audio — every appearance, attributed to the second.
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Thank you, Andrew.
Yeah.
For sure.
Yeah. I mean, just from a very elementary level, peptides are just chains of amino acids. So amino acids, all naturally occurring molecules. We call it a peptide if it's 40 amino acids or less. Call it a protein if it's 41 amino acids or more. The body makes, I think the last I read, 300,000 peptides. So it's a massive number.
We probably therapeutically are using closer to 150 over the years, which is obviously tiny compared to that. So to your point, this is blossoming. We've been using peptides for about eight years, a long time, but still very early in our understanding of how best to use peptides and how clinically we're going to get the most out of them. So it's exciting.
I think the weight loss aspect has only been a couple years. I mean, it's been tremendous how it's accelerated to, like, literally becoming the number one prescribed in America. You know, semiglutide ozempic was approved longer than that for type 2 diabetics, helping with, you know, glucose control and helping with glucose utilization.
And what they found as a side effect was that these people were losing weight. And then that word caught on. And what's interesting, and I don't think most people understand this, most of the medicines prescribed, particularly in America, are prescribed off-label, meaning they've never, ever been approved for what they're used. Isn't that right? Yeah, the vast majority. Yeah, are never approved.
So as a physician, I'm allowed to prescribe any drug for any reason I want as long as it's been approved for something, right? As long as we're safe, right? We don't want to be cavalier about this and renegade and do all these things that are out of bounds. But that is the truth. So semaglutide is a great example being used for helping people, diabetics, type 2 diabetics, lower their blood sugar
And then it got to, well, now let's help diabetics lose weight, right? Because diabetics struggle with weight, the insulin resistance. And then it became, well, even if you're not a diabetic, could you benefit from losing weight? Well, heck yeah, right? I mean, look at the amount of obesity and people who are overweight and having trouble maintaining healthy weight.
It's exorbitant in this country and certainly worldwide. So then it spread internationally. It did eventually get FDA approval specifically for weight loss. But, you know, at first, no, it's been just for type 2 diabetics to help with glucose utilization. And, you know, we've been using primarily trisepatide, which is like semi-glutide version 2.0, mostly for the past two years.
Have learned a tremendous amount. And my opinion's actually changed from working with people.
Yeah, I agree. Both have their place. My philosophy is I want everyone to have access to things that are, number one, safe, that propel them to look, feel, and perform their best. And if that means, right, if it was just about if I can exercise my way out of this, eat my way out of this, meaning lose weight, change my body composition, why do we have an epidemic here?
you know, of so many people who struggle with that because it's really hard, right? And we don't totally understand it. I'm not saying that, yeah, the processed food thing is a massive problem. I mean, I know that's come to light recently with people pushing for us to take a look at food companies and the quality of our food, which is amazing.
But if people aren't interested in doing better for themselves and, you know, this is may not make sense, but I think it does. The analogy I use is I like to help people win the race first, which then helps them motivate to train for the next race. Right.
And this kind of goes against the grain of conventional medicine, which is, you know, if you want to train for the race, you have to, you know, run a certain number of miles. You have to sleep a certain way, have to eat a certain way. You have to do all the things, struggle to get there. Right. And losing weight is a struggle.
And the way I look at it, if I can help people lose weight first, literally, by using something like Terzepetide, semaglutide, and I've seen this, they're now excited. I mean, I met with a client yesterday here in Los Angeles, and she literally looked at me and said, you've changed my life. She goes, I am a super successful woman in my company, with my family, with my kids.
Everything's great, but now I love my life. My workouts are better. I look better. My clothes fit better. I am super excited about waking up every morning. Like she is there. And that is what it's about, right? And so for people, if you can help them achieve their goal first, then they're going to be motivated. The light bulb turns on, they're going to be like, wow, I want more of this.
And that's the aha moment that I love helping people with. So at first I was like, oh, we got to be really cautious with this. Same thinking. Like I don't want people to lose too much weight. Like this is a problem. Are they going to be dependent? Unlike the notion that you have to take something the rest of your life.
And I'm not saying it has to be the rest of their life, but when something works, and as far as I can tell, it's very safe, I think it's worth discussing. And I like people having those options at least.
I think part of that, yeah, resistance training. The other thing I would say is from what we've seen is when people are using the conventional dosages, they're losing weight too quickly. And so what we do is we get both semi-glutide, mostly triseptide compounded, and that allows us to use basically micro dosages and start very low in terms of dosage and go slowly with people.
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