Dr. Craig Koniver
speaker
302 appearances
1 recordings
1 series
first heard Oct 2024
last heard Oct 2024
Dr. Craig Koniver’s voice in public audio — every appearance, attributed to the second.
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But these compounding pharmacies, it's been a huge blow because they've been told they cannot use these agents.
the compounding pharmacies are distinct from these other black and dark gray sources in that they actually can establish purity they are designed to be injected into humans and they have a totally different standard right so they and i think it's confusing for people when they hear compounding pharmacy they thought fringe they're not friends they're fda regulated they're board of pharmacy regulated in every state they are monitored they are inspected all the time i've worked with compounding pharmacies my whole career
which is going on close to 25 years now. Just like anything, there's some amazing compounding pharmacies and there's some not so amazing compounding pharmacies which cut corners. The ones we work with don't cut any corners. And I know that because they're inspected all the time, right? And it's a big deal to them. And they want to do it right with purity, with processing and making sure that
that anything they make, especially a sterile compound, which is going to be anything injected, you know, eye drops, things you inject in yourself, whether it's IV, sub-Q or intramuscular, they're considered sterile. They have to then be tested by an outside lab to make sure purity, make sure that there's no endotoxins, things like that. It's highly regulated and it's a big deal for them.
And it's a big deal for the physicians who prescribe with them, which I appreciate because the advantage of a compounding pharmacy is we can tweak the dosage. We don't have to use a standard set dosage. We can combine things synergistically to get one plus one doesn't equal two now, it equals four. And that to me is a huge advantage.
Just like we were talking about with the GLP-1, semaglutide and terazepatide, we get those compounded. So that, you know, we have the compounding pharmacy we're using now, we're making a unique combination of terzepatide and semirelin, right? Which will address some of this muscle loss that people are getting. So we can combine that.
Exactly. Yeah. And so you can do things like that with a compounding pharmacy. But again, just to make sure people understand, compounding pharmacies are highly regulated, highly regulated. Again, there's always going to be bad apples.
But physicians who know how to work with compounding pharmacies, I think, provide access to things that these conventional, both pharmaceuticals and conventional pharmacies can't.
Yeah, and who's developing a relationship. So we, for any peptide that we use, we meet with the patient. We make sure they're a good fit. We make sure that there's no contraindications.
We also can recommend and specifically dial it up or down, whatever it is, come up with this is what we think you should use based upon your life experience, the medicines you're taking or not taking, the conditions you're treating or not treating. I think that's really important. Again, I'm biased being a physician. My whole goal is to get to know patients.
That's why I'm here is to kind of walk that walk and help people in that regard. And if someone's out there on the internet doing it themselves, they're walking in kind of on their own. And so not to make it like everything bad is going to happen, but when you have the help of someone who has experience, that goes a long way. I think particularly with something like this.
Well, and then taking a step further, you know, getting away from just peptides. But I remember this was, I don't know, 15 years ago, someone was taking advice from a very famous doctor on TV about taking an oral compound to lose weight. And they called me up and they said, I'm having terrible headaches, terrible headaches for days. They came in, their blood pressure was through the roof.
You know, like, I don't remember the specific numbers, but let's just say 220 over 140. And normally it's 120 over 80. Well, did you take anything differently? Yeah, this doctor recommended I take this weight loss compound, right? So the problem is people have access to all this information.
But if they're not under the guidance of a doctor to help clean up the mess, and we clean up the mess, and not that there's always mess, but this is what we enjoy doing. As a physician, we've seen the darkest of dark. We're able to help people when things don't go perfectly planned, right?
And I think that's a big deal, you know, particularly when there's lots of these tools and they're exciting tools and they're great tools.
And fortunately for me, I've been in this space longer than most that I've just, you know, built up a large repertoire of experience of observing people and working with people and seeing we got to tweak this, we got to nuance this, or sometimes we don't ever want to use this again. You know, this is not for most people. Yeah.
Yeah.
So there's a new compound, newer, peptide called, shortened for PDA, pentadeca-arginate. It's basically the same molecular structure as BPC, except they've swapped out an acetate for arginate. One amino acid substitution. Correct. One amino acid substitution. And so we're using that and having really good results.
Certainly, it's early in the game of using PDA, but it seems very close to BPC in the clinical responses we're getting from our patients who are reporting back decrease in inflammation, all these wonderful things that we used to see with BPC. And I think... I surmise that this is how it's going to be with all of these peptides, right? Because again, peptides are just chains of amino acids.
Certainly a lot of people smarter than me trying to figure out how do we then create other types of amino acid combinations, i.e. peptides that do similar actions to BPC, to thymus and alpha, to ipamirone, to TB500, on and on and on. So I'm hopeful in that regard. And I also, you know, some of my patients work at the very highest level of the U.S. government.
Showing 61–80 of 302 · page 4 of 16
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