Dr. Craig Koniver
speaker
302 appearances
1 recordings
1 series
first heard Oct 2024
last heard Oct 2024
Dr. Craig Koniver’s voice in public audio — every appearance, attributed to the second.
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They are well aware of this and who have assured me they're going to look at this, that this is serious, you know, because they've been using peptides. And they're concerned that, oh my goodness, the FDA came in and changed the game. It's been a huge setback. for all of us?
And a good starting dose, so to make it really clear for people and helpful, 250 micrograms to 500 micrograms. We're using 500 micrograms injected daily. Daily, again, we like Monday through Friday, take the weekends off. That's a good dosing schedule. We'll see how that goes. We probably can use larger dosages. That's conservative. But that's a good starting point for people.
Yeah, and we were using BPC intravenously as well. Patients would come in and, oh, tweak my knee, tore my ACL, tore my meniscus, whatever. You can give them BPC essentially as a bolus intravenously. my goodness, that made a difference. Now that using something intravenously from the pharmacokinetic standpoint, it's not going to last in the system very much. It's more of a spark.
Whereas if you use an agent subcutaneously, you're going to get more of a long lasting, you know, again, not terribly long lasting with peptides, but longer than using something intravenously. Kind of the sweet spot was certainly using both. You could use something as a spark to initiate that anti-inflammatory cascade, then follow up with a subcutaneous dose.
Yeah. You know, testosterone is a great example because, like we were saying, I don't ever want to manipulate hormones. You know, growth hormone is another example. I don't ever want to manipulate that, meaning, you know, providing it to people more than they would get in nature.
This is why I actually don't, a little bit off topic, like when people use testosterone pellets or any sort of pellet therapy because you're exposing people to a concentration of hormones we would never, ever see in nature. I would prefer people inject it where you're going to get some variation in dose on a day to day basis, which we're humans.
So we do get some day to day variation or topically or under the tongue or something. Peptide, same thing. I don't want to manipulate the hormones, right? I want to just stick within kind of the highways of the lane, swim lanes for how they should operate and then take advantage of that.
And that's been a safe way to do it as opposed to and I've seen it, you know, talking about another peptide, which is Ipermorelin, a growth hormone releasing peptide. Ipramirelin, you inject under the skin, travels up to the pituitary, the posterior pituitary in the brain, which is responsible for putting out growth hormone.
That growth hormone then leaves the pituitary, enters the bloodstream, travels to the liver, where we make insulin-like growth factor one, which then enters the circulation, is very anabolic, meaning growth, healing, mending. You know, as we get older, we make less growth hormone. As we get older, we wear down. Obviously, we get, you know, degenerative conditions.
Part of that, I don't know what part, for everyone it's a little bit different, is because of our hormonal decline. And so when you can give something like ipamorelin, and we can talk about others, you're actually helping not only push out a little bit of growth hormone for people. We are directing when you push it out, right?
We think that's why it's important for people to be asleep by 10 p.m., between 10 p.m. and 2 a.m., because we think that's the largest pulse of growth hormone during the 24 hour period. Is that right?
Yeah. I mean, that's how I learned it. I agree with you. It feels true to me as well. But taking advantage then of, you know, injecting something like ipramirelin at bedtime, then you're going to, you know, within a few minutes. And with ipramirelin, it's interesting because people will get a little flushing, tingling at times.
And what I've seen with the point I'm making is there are some physicians and some pharmacies which, you know, the dosage of ipramone and most of these growth hormone-releasing peptides should be 100 micrograms. That's the max dose to bind the receptor. And, you know, what I've seen is with ipramone, rare, but some people do get anaphylaxis. And it's happened.
And I think that happens when people are pushing it and giving more than they should. And I've heard of that. And they're giving 200, 300, 400 micrograms at a time, which is a big dose. Now what they're getting is the client, the patient is like, oh my gosh, I feel this amazing flushing. It must be working.
But then you could spiral into, oh, my goodness, I don't feel so good, and your circulation system collapsing.
Yeah.
I agree with that. I agree with that. And that's why I think it's, again, helpful to work with a physician who has experience who can kind of, you know, I think of these peptides as having flavors, particularly the growth hormone-releasing peptides. Ipramerone, very clean.
You know, as long as you stay within 100 micrograms or less, people are going to lean out a little bit, sleep a little bit better. There's no real side effects. They take it pre-sleep. Pre-sleep at bedtime. Without carbohydrates ingested in the previous two hours, correct? Yeah, or 45 minutes technically. Yeah, but that's right.
And then they're saying like growth hormone release in peptide six, GHRP6, which is also going to bind. So I think of ipramarone being the most specific for the growth hormone receptor, but the weakest. So when you inject it, you will get growth hormone to come out and only growth hormone, but it's not going to be a big burst of growth hormone. You inject GHRP6, now you may bind some prolactin.
Now you may bind some ACTH, which is going to have your adrenals put out cortisol. Now you're going to get a hunger response, right? And maybe even have trouble sleeping if you're getting them. You may have trouble sleeping. But where that's beneficial for is if you're looking to put on mass or get strong, GHRP6 is your go-to, right? Because you will increase your appetite.
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