Dr. Dale Bredesen

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108 appearances 2 recordings 2 series first heard Apr 2025 last heard May 2025

Dr. Dale Bredesen’s voice in public audio — every appearance, attributed to the second.

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Dhru Purohit Show · How to Make It To 100 With A Sharp Brain And Good Mobility · 19 May 2025 podcast
Yeah, it's a really important point. So if you're 40 or over, we recommend that everyone get a cognoscopy. So we all know when we turn 50, what are we supposed to do? We're supposed to get a colonoscopy, and it can really reduce your risk of dying of colorectal cancer. Of course, pap smears did a tremendous job for reducing cervical cancer.
And by the same token, getting a cognoscopy if you're 40 or over, and especially if there's been any sort of family history, but in general, for all of us, because we are all at risk. It dwarfs the pandemic. We're talking about 1 million who've died in the US from the pandemic. About 45 million of the currently living Americans will die from Alzheimer's if we don't do something about it.
So again, nobody should get this. There's a tremendous amount you can do. Get a cognoscopy, which is some blood tests and a simple online cognitive test, as you mentioned earlier. and then MRI with volume metrics and some simple things you can do. We talk about the seven basics.
It's a great point. And we see yes and no. So I would say what I'm seeing is about a quarter of the people, their doctor will say, sure, I'll do these for you. No problem.
Yeah, so they're running things, again, which makes sense when you look at what is important for innate immune activation and for energetics. So they're running HSCRP, and they're running homocysteine. And TGF-beta-1 is actually a very good thing to know about yourself, that or MMP9. Again, these are things that are responding typically to biotoxins and other inflammogens.
And then you're looking at your HOMA-IR. So you're looking at your fasting glucose, you're looking at your fasting insulin, you're looking at your hemoglobin A1C, you're looking at your methylation. You know, we're now, there are some new things so that you can now look at your epigenetics. And you mentioned earlier the advanced lipid profile.
So you're looking at, you know, how are your lipids looking and do you have an inflammatory pattern or not? And then you're looking at, do you have toxin exposure? And we see this a lot where people will have biotoxin exposure, often in association with low platelet counts and or low white blood counts.
And this is something that Dr. Joe Pizzorno has pointed out many times in the past, that many of us are exposed to toxins. And one of the things that we see and that we don't often pick up as physicians, is that people will have often low white counts and or low platelet counts. And it's telling you there's something that is interfering with these.
Great point. So if you go back, the toxins that cause cognitive decline break down into three groups. There's the inorganics, and that's air pollution, and mercury, and things like that, heavy metals. Because actually, not only does amyloid, not only is it part of your innate immune system, it is a metal-binding protein, actually quite tightly. So it binds zinc and copper extremely well.
Secondly, organic toxins. So things like formaldehyde and glyphosate and toluene and things like that. But then thirdly, as you mentioned, biotoxins. And these are typically things made by molds, although there are other organisms that make biotoxins as well, but they're typically trichothecines. Those are the ones that I worry about the most because these are made typically by Stachybotrys.
Um, so it's, you know, the, the, the, the five big mold species that you worry about with these are stachybotrys, penicillium, aspergillia, aspergillus, um, ketomium, and walemia. Those are the five typical bad guys. Uh, and so, and they're making things like trichothecines and ocratoxin A and gliotoxin, uh, and things like that, that actually turn out to impact your immune system.
And you know, you're, The mold wants your immune system to be turned down so that it can live, so that it can stay there. And so it is trying to turn that down, unfortunately. And of course, your immune system is saying, no, I want to recognize this and I want to get rid of it. So these are ones that I am most concerned about.
It's such an interesting point. And, you know, it reminds me of these old movies you see, you know, where there are 10 people and it's a rainy night and they're in a hotel together. And then suddenly there are only nine. One of them gets killed and then there's eight. And, you know, they keep looking at each other to say, who is the murderer here?
You know, you're looking at this, now there's seven. Murder mysteries, just like there's one with John Cusack years ago. And so the mold's a little bit like that. It's like, we're looking around like, what is causing this decline? Like, could it possibly be this mold that like is everywhere? And, you know, it kills me to say that it does seem to be a common contributor.
I asked the physicians who were doing the trial, what percentage of your patients do you think mycotoxins are a contributor? The answer was 80%. I couldn't believe it. So now that's not to say it's the only contributor. It's one of many.
Would they put it in the top five? Yeah, I think for sure it would be in the top five. I think in many it would be in the top three. What we find, we published this years ago, that probably 15 to 20%, it's the main thing. It's the main thing. It's the thing that you're really out of focus.
But Dr. Christine Burke over here near Sacramento, I thought made a really interesting observation and others have seen this, but I think she brought up a really good point. which is when she sees her patients and she does exactly the things you're talking about, she gets them to be metabolically flexible, she gets them to do the basics. We started talking about the basic seven.
So when she does the basic things, she buys them nine to 12 months, they do well. And then after that, if she doesn't find the specifics that are causing this, if she doesn't find, oh, there's pathogens that I need to deal with, or there's mycotoxins, if they don't deal with those specifics, they won't sustain that improvement. But I thought it was a very important observation
And we've seen it before. And Julie Gee, who works with us and who herself is APOE4 for, she's the one who founded the website, APOE4.info, and has done such a wonderful job and has taken herself from 35th percentile to 98th percentile. She's sharp as a tack. And she's now over 10 years on this overall approach. She had about four years. So she was doing things, you know, really, really well.
Got on the right diet and did the right, you know, basically resilience, getting herself resilient. And she bought herself about four years or so. Then she started noticing a little bit of backsliding. This was now several years ago. And she contacted me and I said, well, you know, there are some things that haven't been checked on you, and you need to be looking into these other things.
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