Dr. David Allison

speaker

936 appearances 1 recordings 1 series first heard Mar 2026 last heard 31 Mar

Dr. David Allison’s voice in public audio — every appearance, attributed to the second.

Trend

recordings per month · last 12 months

Recordings per month over the last 12 months — 1 in all, peaking in Mar 2026 with 1.

newest first · ▶ plays the moment

So the idea that we all respond differently to things is usually not demonstrated.

It's usually assumed.

Even the well-meaning research-based clinician, scientist, who says, don't tell me this is not evidence-based.

Look at my randomized controlled trial here.

Look at the fact that some people had huge reductions in body weight on this drug and some small or none or gained weight.

Look at the change in LDL cholesterol when I put people on this diet versus that diet.

Look at how variable it was.

And they say, you see great heterogeneity response.

And I say, no, I don't see that.

What I see is great heterogeneity of outcome.

If outcome equal response, I wouldn't need control groups in studies.

So let's say you and I both go on a weight loss drug.

We're in a clinical trial.

You lose 10 kilos.

I lose zero kilos.

The investigator comes along and says, good responder, non-responder.

I say, no, good outcome, not so good outcome.

However, maybe what happened is the drug caused you to lose five kilos.

You happened to also get the flu during that time and felt ill as heck, and that caused you to lose another five kilos.

Your total weight loss was 10 kilos, but only five was due to the drug.

Showing 501–520 of 936 · page 26 of 47