Dr. David Allison

speaker

936 appearances 1 recordings 1 series first heard Mar 2026 last heard 31 Mar

Dr. David Allison’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Mar 2026 with 1.

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I lost zero kilos.

It turns out, though, that right before I went on the study, I moved in next to a donut shop.

Bad move, friend.

Bad move.

And I'm just loving it.

And I'm eating donuts every day.

There's some good donuts over there.

And had I not been on the drug, I would have gained five kilos.

So the donuts caused me to go up.

The point is that the drug pulled me down five, the donuts pulled me up five.

Yeah, you know, you integrated zero.

But in fact, you and I had exactly the same response.

The drug caused each of us to gain five less kilos or lose five more kilos than we otherwise would have done.

But it's hidden behind other factors in our lives, the flu, the donuts.

The standardized randomized control trial doesn't estimate that.

It estimates the average effect.

So it's not that it's wrong when I say across all people taking the drug, they lost five kilos more on average than people not taking the drug.

The drug caused a five kilo weight loss on average.

That's true.

In that hypothetical I've given you, it caused exactly five kilo weight loss for both of us, but it's not obvious.

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