Dr. David Perlmutter

speaker

585 appearances 1 recordings 1 series first heard Jul 2026 last heard 15 Jul

Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.

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Be Well by Kelly Leveque · 393: Alzheimer's Starts Decades Before Symptoms…Here's Why | David Perlmutter · 15 Jul 2026 podcast

You know, it used to be that we really wanted to tease apart what is unique about Alzheimer's, what is unique about Parkinson's so that we can develop drug approaches for each and every neurodegenerative condition.

But realize what I just told you is that they are all unified by this main upstream mechanism

the shift of the microglial cells from being supportive to being destructive.

So, you know, what I'd like to do is really move into, well, what is it that shifts these microglial cells?

And I have to say, I don't think I've said this on any podcast before, but I find this to be very, very enjoyable because it's just really very exciting because

This unites really what I've been doing for such a very long time.

Look, males get polycystic ovarian syndrome.

It's not called that anymore, but really the same sort of thing happens in males as well.

So what you just did was you hit a home run.

It's the same stuff, different day.

It really is, SSDD.

And you are exactly right.

And what is so incredibly exciting about it is a term that has been developed called immunometabolism.

And that means that our metabolism, the shape of our metabolism, how we're controlling our blood sugar, insulin functionality, our blood pressure, our lipids, all of the things that contribute to

the metabolic markers that we're so fond of looking at, influence the immune system.

And when we become metabolically dysfunctional, then the immune system throughout the body is challenged and will manifest, as you well described, as issues, autoimmune conditions that you've mentioned.

And the brain, oddly enough, is part of the body.

So when we become metabolically dysfunctional, our microglial cells sense that

and shift to being the evil twin.

And when they do, their metabolism changes dramatically.

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