Dr. David Perlmutter
speaker
551 appearances
1 recordings
1 series
first heard Jul 2026
last heard 9 Jul
Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
You do have your nitrate to nitrite conversion bacteria on the dorsum of your tongue.
So let me unpack a little bit further this whole idea about and you called it out, n you know, don't castigate the fireman or blame the fireman who's at the fire.
We want to be as upstream as we can.
And it it turns out that
This shift of the brain's immune cells from being supportive to being destructive, two things are important.
Many things are important.
Number one, we can control that, and we'll talk about how.
Number two, it looks like this is the fundamental mechanism in all neurodegenerative conditions, whether it's frontotemporal dementia, Parkinson's MSA, progressive supernuclear palsy, Alzheimer's, you name it.
Whatever makes the good brain go bad.
It's playing a role in what makes head injury worse.
It's what is activated in long COVID, in um post-traumatic stress disorder, in major depression.
All of these things are associated with the shift of the M2 supportive microglia to the destructive.
form of microgrid called M one.
And you can even image the brain in living people to show that it has shifted.
Well, oddly enough.
I know what you're gonna say.
Well, first of all, the shift from M two to M1 is characterized by a drop in mitochondrial function.
Exactly.
In fact, they uh the the full-on M1 phenotype uh is one that doesn't even have functioning uh mitochondria to any significant degree.
Most of the energy is coming from a far less efficient uh process called glycolysis.
Showing 221–240 of 551 · page 12 of 28
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