Dr. David Perlmutter
speaker
551 appearances
1 recordings
1 series
first heard Jul 2026
last heard 9 Jul
Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
He saw the whole area of the part of the brain that makes dopamine for movement, called the substantia nigra, was totally destroyed and the microglia were digesting those cells.
Thirteen years later, these were M one active microglia.
So we really don't want those.
Well we let's Okay, we want them when we need them.
We want them when we need them in an acute infection, acute injury, but then they need to be put to rest.
With the fire engine has to come out of the firehouse.
When the fire's put out, we need it to go back in and not keep spraying the water.
You and uh Phineas.
This is it, what a great question.
And what happens of course when you have an injury?
The M two microglia do need to shift to M one as an emergency response.
The problem is then they as we mentioned earlier, we gotta put the fire truck back in the firehouse.
They need to stop.
But what keeps them in their destructive condition in the M one configuration?
Well, if you had preexistent metabolic issues, for example, we know that, for example, in a large population set, uh that uh a study demonstrated that type two diabetics across the board had longer hospitalizations with head injury and more protracted issues once they were discharged in terms of the degree of injury.
The the injuries were pretty much stratified, so they were equal in both numbers.
non-diabetics and diabetics, but yet if you were diabetic, you had a worse outcome.
Why?
Because that's a situation, a metabolic situation over which we have control that keeps those microglia shifted in their destructive phenotype.
Everything about getting over a head injury is about reverting the microglia back.
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