Dr. David Perlmutter
speaker
551 appearances
1 recordings
1 series
first heard Jul 2026
last heard 9 Jul
Dr. David Perlmutter’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
Yeah.
So I think that uh less you know, I I you know, we we our messaging was different years ago based on what the science was telling us.
A U-shaped curve.
Right.
And that one glass of wine for women per day was better than zero and and better than two.
So it was, you know, there was a sweet spot.
But I think more data's coming out indicating that it's just not worth it.
And in fact I can't think back when I had my last drink.
But I think you bring you bring up a very good point about the gut permeability issue.
People don't talk about the microbiome changes.
And therefore the gut permeability issue and the LPS liberation and how that augments inflammation in the body, that makes its way to the brain.
That brings us to our our discussion today.
What happens when there's inflammation in the body, anywhere in the body, and the brain knows that's going on?
What happens is our supportive M two immune cells in the brain, microglia they're called.
Which are normally nurturing our neurons, nurturing synapses, nurturing the growth of new neurons and synapses and keeping the blood brain barrier functioning, when they are exposed to inflammation coming from even the gut.
As well as uh innumerable other influences, they shift to being what I call in the book the evil twin.
And they're now destructive, they're eating away at our synapses, they're creating an environment that uh is not good for neurons.
These are the focal point in neurodegenerative conditions now.
It's not this beta amyloid accumulation that is just not so I can be very clear, accumulation of beta amyloid is not the
cause of Alzheimer's disease.
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