Dr. Karan Rajan

speaker

2,601 appearances 14 recordings 1 series first heard May 2026 last heard 7 Sep

Dr. Karan Rajan’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 14 in all, peaking in Jun 2026 with 5.

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Dr Karan Explores · Weight Loss Surgeon: Why Exercise and Calorie Cutting Doesn’t Work | Dr Andrew Jenkinson · 20 Jul 2026 podcast

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So, you know, when we're thinking about weight, I mean, we've talked about genetics and the environment as well, but fundamentally there is a

gut driven and neurological process which also makes us physiologically want to eat food and also know when to stop and that system can be miscalibrated and sometimes dysregulated.

Uh people with obesity, it may be dysregulated, um, you know, and they have this food noise, uh, which is uh, you know, a popular phrase these days to describe that urge to eat.

But fundamentally it comes down to hormones.

Can you explain

What are these hormones that are driving and influencing our appetite?

I guess a lot of people talk about we are now living in a obesogenic environment, which I guess is in part true.

Perhaps it would be more accurate based on what you've said to say that we live in a insulogenic environment where maybe the consequence of ultra processed food, by that I mean high fat, high salt, high sugar, devoid of fiber, making us consume more, chronically raising and having excess sugar.

driving up the insulin and increased adiposity, also driving up the insulin with insulin resistance.

And as a byproduct, the high insulin and insulin resistance, you're getting the leptin resistance.

So we cannot

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