Dr. Mike Roberts
speaker
1,217 appearances
1 recordings
1 series
first heard Jul 2026
last heard 8 Jul
Dr. Mike Roberts’s voice in public audio — every appearance, attributed to the second.
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And then we sent him some muscle from a training study that we did.
across species what we see with mechanical overload in the mice and in the humans is that when you see this increase in fiber cross-sectional area it is due to the increase in the number of myofibrils so those myofibrils in terms of their size sort of maintain this sweet spot that's relatively conserved and so applying you know resistance training you're just going to see a larger
radial increase in cross-sectional area of that cell.
And that's due to the addition of myofibrils, if that makes sense.
Other things that happen with resistance training, of course, is sort of this proportional increase in everything else in the cell.
So we have the mitochondria.
People conventionally look at it as like this is the powerhouse of the cell.
They, you know, this is ex-phys 101.
It produces the lion's share of ATP, which is certainly true.
There are other
roles of the mitochondria in terms of, you know, molecular signaling, Ross handling, things like that.
But as you resistance train, that's been kind of one of our questions as well.
What happens to mitochondrial content?
Because some of the studies would indicate that you have a dilution effect, which is to say, as the cells increase in size, certainly we have this proportional increase in mile five roles, but that comes at the expense of not expanding the mitochondria.
We took different approaches throughout the years.
One of the markers that has been conventionally looked at is citrate synthase activity.
And a lot of studies showed that with gen pop, you take them through 10 weeks of resistance training, pre to post training, you see a decrease in CS activity, which would then reflect the dilution of mitochondria, which is to say the myofibrils sort of, the growth of the cell and expansion of the myofibrils outpaced the expansion of the mitochondria, you know, reticulum or whatever.
But
Looking at it from immunohistochemistry, we have a 2021 paper by Brad Ruppel
we were convinced that there is this proportional expansion of the mitochondria with hypertrophy, which sort of makes sense because you need that to produce energy for the growing cell, right?
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