Dr. Mike Roberts
speaker
1,217 appearances
1 recordings
1 series
first heard Jul 2026
last heard 8 Jul
Dr. Mike Roberts’s voice in public audio — every appearance, attributed to the second.
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So Adam Sharples, again, go read his papers because his initial work here would indicate that, look, if you train for a period of seven weeks, resistance train, you see hypertrophy, you then take a seven-week period off, and then you retrain for seven weeks.
you not only will get to that initial hypertrophy during the first block pretty rapidly, but you actually exceed that level, right?
So the conferred advantage aspect there is that be it monuclear number increases in retention, be it three-dimensional changes in the chromatin within the nuclei, which leads to this sort of
modeling of genetic materials so that when you retrain, you can express those exercise-responsive genes very efficiently.
That's what we're talking about.
It all hinges on the mononuclei, the number and then the dynamics in terms of how your genes are expressed is what we talk about when we talk about muscle memory.
There is a one-off paper.
It was in older participants.
And what they did was they trained them for a, we'll call it a typical 12 week.
It could have been actually longer.
It may have been like a six month training period.
It was either 80%, you know, one arm training, generally speaking, or it was something to the tune of like 55% one arm training.
six months of that okay clearly both groups are gaining strength i think the 80 is probably getting a little bit stronger etc then they had this like one year hiatus and then they tested at the end guess who was stronger about baseline after the one year hiatus it was the high load group yeah right which is remarkable now the hypertrophy they actually didn't do any imaging i think it was like all circumference tape measure stuff so they didn't have sophisticated methods but i looked at that paper thinking wow
That's crazy.
Which speaks to the sort of the neuromuscular neural aspects of that could be at play as well with, you know, there's some sort of retention of motor drive, central motor drive to the muscle or whatever.
And that seems to be manifested better with higher load training, if that makes sense.
Yeah.
So, to the best of my knowledge...
There have been more sort of sub-chronic studies looking at the effects of proteostasis and muscle protein synthesis, decrements therein with younger and older pops.
We put, Matt and I, with a colleague that Matt had in Orlando, we actually put in an NIH proposal.
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