Dr. Nathan Bryan
speaker
1,178 appearances
5 recordings
3 series
first heard Feb 2025
last heard 3 Apr
Dr. Nathan Bryan’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Apr 2026 with 1.
Appearances
Interestingly, though, cigarette smoke, people who are smoking, we can detect nitric oxide gas coming off the burning cigarette. And we actually did, when I was in Boston, I believe we had a grant looking at the effects of nitric oxide and cigarette smoke on cardiovascular health.
So I think what we figured out was there's so many toxic things in cigarette smoke that it certainly outweighs the small benefit you may get from the little bit of nitric oxide that's found in cigarette smoke.
No, they're nicotinic receptors inside the body. So nicotine is a vasoconstrictor. So when we have nicotine, it constricts the blood vessels. But there are many other kind of extravascular effects of activating the nicotinic receptors and the effects of nicotine. But it makes people feel good. I mean, it's an addictive substance. That's why people smoke.
That's why people dip snuff or chew tobacco. And now you've got the nicotine in the vapes that are rampant. But again... Nicotine is one of these naturally occurring substances, and we have nicotinic receptors just like we have endocannabinoid receptors. So our body is used to seeing these things and initiating some signaling aspect.
But again, in the vapes, there's probably more toxic chemicals in there that outweigh the benefits of a little bit of nicotine.
Not a fan. No, personally, I wouldn't do it. I mean, anything that chronically constricts blood vessels to me is about chemists and physiologists and the biomedical sciences I stay away from.
If we had a Z on the ranking, I would rank it as Z. You'd put it as Z. But right now we're going to put it at F. It's the absolute bottom. And again, for me, it's about what are the risks and what are the benefits? Yeah. And there's really no benefit of seed holes. What are the risks? I mean, we probably don't have enough time on the show to talk about the risks.
But the same people who are saying the so-called experts and nutritionists and epidemiologists who tell us that, you know, seed oils provide some benefit are the same people who told us that cholesterol causes heart disease for the best 30, 40 years. And it's absolutely false. Cholesterol does not cause heart disease. Targeting cholesterol to mitigate or to prevent heart disease has failed.
In fact, it's made people worse. Again, let's talk about what cell biology and the effect of seed oil on human health. So every cell in the human body has a phospholipid bilayer, a cell membrane. And the fluidity of that cell membrane allows for intracellular signaling.
So the cell senses an extracellular environment, and then it binds to receptors, and through this, really, it's a seven-transmembrane receptor signaling, and then it activates intracellular signaling, turns on proteins, turns on certain genes.
But if we lose that fluidity, if we don't have enough cholesterol in there, or if we have these polyunsaturated fatty acids, these synthetic oils, it completely disrupts the fluidity, completely disrupts intracellular signaling. And we develop cellular dysfunction. And what is that? Well, insulin institutes or causes an intracellular signaling, right? We get insulin minus insulin receptors.
The inside of the cell gets the signal. Glut4 goes to the membrane, brings in glucose, and we clear it from the circulation. But what happens when insulin doesn't transduce that signal to bring in glucose because of lack of cholesterol, because of lack of the fluidity and the signaling aspects of seed oils, we develop insulin resistance and diabetes.
And the worst, the half-life of these is about 600 days. And a half-life means that in 600 days, half of the seed oils that you had incorporated in your cell membranes is gone. And in the sciences, we need at least five half-lives to completely clear over 99% of that. So you need 10 years. If you consume Cetol, it takes 10 years to remove that exposure from the incorporation of human cells.
So they provide zero benefit. And it's not just an acute injury. This is a chronic thing. This is what leads to chronic disease. When you lose the activity of the functional unit of life, which is the cell, you get sick, you can't perform, and your health becomes compromised.
Yeah. Because everything we know about cell signaling and signal transduction from the outside sensing to inside regulation, whether it's transcriptional, translational regulation of proteins and enzyme function, I mean, it all depends on the integrity of the cell membrane and how we can transduce that signal.
I don't think, not to kind of convincingly tell us that this is a problem. I mean, the standard of care is you look at a standard lipid panel, cholesterol, HDL, LDL, triglycerides. I mean, those really don't tell us anything. Total cholesterol, you know, the people who live the longest typically have cholesterol between 240 and 280 based on the Framingham data. Triglycerides are inflammatory.
We have to get our triglycerides less than 150. But if you do an advanced lipid panel and look at certain lipoprotein particles, the size, the number, and the amount of oxidized particles, that tells us really how inflamed the cell is and how inflamed that person is.
But you have to ask for that because if you just go to your primary care physician and they do a blood draw, they're just going to give you a standard lipid panel, which to me doesn't provide any – it certainly has no prognostic value. You've got to dig a little bit deeper.
Certainly these C-dolls are inflammatory. So you'll see inflammatory markers, whether it's C-reactive protein. These are kind of lead to lipid peroxidation and inflammation within the cell membrane. So you may see ferritin go up. You may see uric acid go up, C-reactive protein. Those are kind of the acute phase inflammatory markers that you may see in people who are chronically consuming C-dolls.
And they'll probably have metabolic disease.
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