Dr. Nathan Bryan
speaker
1,178 appearances
5 recordings
3 series
first heard Feb 2025
last heard 3 Apr
Dr. Nathan Bryan’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Apr 2026 with 1.
Appearances
or abroad, there was no physician in his right mind that would say, I'm going to give you an antibiotic, and I want you to take this every day, sometimes twice a day, for the rest of your life. Why wouldn't they do that? Because today we know that destroying the microbiome, the bacteria that live in and on our body, causes systemic disease.
The bacteria that live in and on our body outnumber human cells 10 to 1. And sure, there's some infectious pathogenic bacteria that cause disease, that cause infections. But for the most part, if we can maintain a healthy microbiome, then those bacteria kind of police the bad guys and keep them at bay.
So mouthwash destroys the microbiome, shuts down nitric oxide production because it's killing these nitric oxide producing bacteria. And then what are the consequences of that? We see an increase in blood pressure, which is the number one risk factor for cardiovascular disease, number one killer of men and women worldwide. You lose the protective benefits of exercise. And that's just a short list.
You develop sexual dysfunction because if you can't make nitric oxide, can't dilate blood vessels, can't get an erection. And so that's a major problem. And all you have to do is look at the numbers. Two out of three Americans use mouthwash every day, sometimes twice a day. Two out of three Americans have an unsafe elevation in blood pressure.
And prescription medication isn't bringing it down because there's no prescription antihypertensive medication that's targeted toward the oral microbiome. Antiseptic mouthwash, fluoride is absolutely one of the worst things you can do for the microbiome, nitric oxide production, and overall health.
So it's certainly an F. I mean, it's definitely an F. So we're going to put seed oils as an F. So we're talking about daily chronic antiseptic use. So just like if I get a scrape or something, it's infected and I have systemic inflection or at risk of developing sepsis. I want an antibiotic. Don't deny me an antibiotic, right? It's effective treatment for infections.
If you've got dental patients who have horrible, poor oral hygiene and really pathogenic bacterial infections that could cause them to have a heart attack or stroke or increase vascular inflammation, those patients may need an acute antiseptic kind of treatment, whether it's chlorhexidine or something to kind of eradicate, but you can't do it every day, right?
Just like you can't take an antibiotic every day because of the complete destruction of So we have to, and medicine is risk management, do what's best to get out of the acute critical phase. But then you've got to support the microbiome. You've got to support the body in eliminating daily chronic antiseptic use, whether it's antibiotic, fluoride, or antiseptic mouthwash.
You've got to get rid of it.
Why does poop stink? Why do your armpits stink? Why do some people stink? Why does your breath stink? It's bacteria. It's dysbiosis. So if you can maintain a healthy microbiome, you're not going to have bad breath. Your pits aren't going to stink.
And so what we've done, and we've been working on this for probably six years, trying to figure out, I know in dental medicine, you have to eradicate the oral pathogens. But more importantly, we have to support the healthy microbiome. And that's why, you know, it took me five or six years to develop a toothpaste because what's the purpose of toothpaste?
Clean the teeth, clean the biofilms on the teeth, give the body the minerals it needs to enhance mineral density of the teeth, maintain healthy gums and normal pH, but more importantly, support the oral microbiome. And how do you do that?
Well, you create a toothpaste that's free of any kind of detergents, fluorides, antiseptics, but then create an environment after you brush your teeth that supports the repopulation of the healthy microbiome, improve the diversity of the microbiome, normalize the pH, and that's through our oral care products.
So we're developing a nitric oxide-friendly toothpaste and a nitric oxide-friendly mouth rinse.
You know, I was the person who developed these strips. Wow. In 2009, I developed these salivary test strips and created this kind of semi-quantitative colorimetric test strips. I filed patents on them when I was a professor at UT Medical School in Houston. Years later, we abandoned the patents because this chemistry that we're capturing on this test strip is old chemistry.
It's called the grease reaction. Grease. The grease. G-R-I-E-S-S. Okay. It was named after, I think, a chemist who developed that. It's a diazonium salt that forms that turns a pink color. So we can absorb it. We can detect it at 540 nanometers. So it should turn pink. And it's basically an acidified sulfanilamide reaction with nitrite.
Very complex chemistry, but it creates this colorimetric reaction that we can quantify. The reason that I abandoned the patents and the reason that I don't rely on them anymore is because there's false positives. So there's really no false negative. And really at the end of the day, when people understand what we're measuring and what it means, then I think they can provide value.
But people would use this test strip and think, oh, this is nitric oxide test strip. It's not a nitric oxide test strip. Nitric oxide is a gas. Once it's produced, it's gone in less than a second. What we're measuring here is salivary nitrite and the ability of the oral microbiome to recycle nitrate from the diet into nitrite. Then we swallow the nitrite in our saliva.
We get nitric oxide in the stomach. And the example came years ago, probably 10 or 12 years ago. We were demoing these test strips, I think, at a compounding pharmacy in Austin. And this 50-year-old guy walked in, severe obese, morbidly obese. His blood pressure was through the roof. He was diabetic. He hadn't had an erection in 10 years.
And obviously the clinical symptoms of nitric oxide deficiency, complete nitric oxide deficiency. He goes, oh, well, let me test this. He turns bright pink.
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