Dr. Tony Wyss-Coray
speaker
644 appearances
1 recordings
1 series
first heard Feb 2026
last heard 23 Feb
Dr. Tony Wyss-Coray’s voice in public audio — every appearance, attributed to the second.
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Appearances
That would be very interesting to do.
I mean, we looked at cerebrospinal fluid, but it's of course different.
And that
again, differs dramatically with age.
The composition changes dramatically.
And I had a fellow who was heroic enough or crazy enough to collect young CSF from animals, from mice, and then infuse it via a pump.
over a month into old animals.
And she could show that you can regenerate the brain, improve cognitive function in these mice.
And oligodendrocytes, these cells that wrap the connections between neurons, it's like they produce the plastic around the wire, right, if you will.
They were the strongest target if we looked in an unbiased way.
And so she's studying that now in her own lab.
But it shows you in another way how a fluid changes from young to old, and the young fluid somehow has beneficial factors that benefit the old brain.
And so I wouldn't be surprised that...
There could be beneficial factor in the glymph or the lymphatics that might benefit an old organism.
We thought about it, but I think in mice, it's extremely difficult.
There's also the interstitial fluid itself that people have collected.
But they're usually collected by infusing artificial spinal fluid and then you almost wash out what it's in there.
People have used that in the neurotransmitter field and also more recently to look at, you know, a beta or accumulation of protein deposits in the brain.
CSF is no problem, yeah.
Okay.
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