Dr. Tony Wyss-Coray
speaker
644 appearances
1 recordings
1 series
first heard Feb 2026
last heard 23 Feb
Dr. Tony Wyss-Coray’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Feb 2026 with 1.
Appearances
So we measure proteins in the CSF
And again, thousands of proteins.
And we asked, are there proteins that correlate with cognitive function, with resilience or decline?
What's really interesting is, so we did this in a completely unbiased way.
You find proteins that go up and go down together with cognition, so that positively or negatively correlate.
And almost all the top proteins are synaptic proteins.
We then use the top two, the one that goes up the most and goes down the most and made a ratio of the two.
And that ratio is a very strong predictor for cognitive resilience or decline.
And what's scary is that ratio continues to change from early adulthood.
So you get a continuous basically degradation of that signal.
And we get a very prominent risk prediction between the top and the bottom quartile.
And this is based on 3,000 individuals where we had CSF from.
And it's independent of pathological markers.
So we also had people with Alzheimer's disease in there at different stages of disease.
So if you look for what is...
only predicted of cognitive function based on a memory test, we find these synaptic proteins are very strong predictors.
So again, suggesting that the composition change, and then you can ask, is this a reflection of the change or is it actually driving the change?
And it seems to be both again.
Yeah, that's very interesting.
So John Long at Stanford has a lab and he looked at metabolites in the blood of dogs, sprinter dogs, horses that do races, and then also humans, sprinters.
Showing 461–480 of 644 · page 24 of 33
← Previous
Next →