Dr. Vivek Lal

speaker

549 appearances 1 recordings 1 series first heard Aug 2026 last heard 4 Aug

Dr. Vivek Lal’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in Aug 2026 with 1.

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The Human Upgrade: Biohacking for Longevity & Performance · I Take 150 Pills a Day (But This One Is My Workhorse) | Resbiotic : 1513 · 4 Aug 2026 podcast

Air is medicine.

Why just food as medicine, right?

We eat three times a day and food becomes medicine, but we breathe 20 times a minute, 30 times a minute.

So what we breathe in every second does make your lung resilient to or susceptible to a second hit or a third hit.

So in late 2000s, I think it was 2006 and 7, NIH came up with the human microbiome project.

Lungs were not even an organ, right?

We all thought that lungs were sterile.

So our lab, I was a professor at University of Alabama at Birmingham, our lab and several other labs around the world started looking at the lung microbiome.

So there is a lung microbiome, but different from the gut in the sense that gut is pretty rich in microbiome.

The lung microbiome is extremely low biomass, but it doesn't mean that it's not there and it's not important.

So it's low in biomass, but it's critical in making the lung susceptible to inflammatory pathways or resilient to it.

So we started studying the mechanisms.

I was a lung molecular biologist and we were looking at

individual mechanisms or molecules, which would increase inflammation, you know, for COPD, asthma, all of these things, how the collagen in the lung breaks down.

We were looking at all omics, right?

Metabolomics, proteomics, microbiomics, and found that microbiomics was very, very effective in trying to accomplish what we were doing.

And that's how we started sequencing lung samples

starting from neonates, because I was a neonatologist, starting from all these premature infants, and then adults with COPD, asthma, and found there was a very peculiar lung microbiome, which would make them either resilient or susceptible to inflammation.

even if you control for everything else so and the microbiome is this just one bacteria or three or no the whole phyla of you know firmicutes right so then we extracted those took it to the lab setting uh grew them on organs like organs on chip and did a lot of gain of function loss of function there and then figure out which exact organisms

what decrease inflammation the most and in what ratio.

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