Erin Allman‑Updyke and Erin Welsh
speaker
988 appearances
1 recordings
1 series
first heard Aug 2026
last heard 4 Aug
Erin Allman‑Updyke and Erin Welsh’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Aug 2026 with 1.
Appearances
No.
Yeah.
No, that's so true, Erin.
Like, I see people in clinic all the time that this happens to, and I just say, blame your parents.
Like, it's probably your genes.
Okay.
So let's then talk about what are some of the big medicines that we use and how do they actually work?
Why are they working?
Right?
Statins.
Statins.
So statins block an enzyme in our liver that's called HMG-CoA reductase.
The Cliff Notes version is that this particular enzyme, HMG-CoA reductase, this one, is the rate-limiting step in cholesterol synthesis in your liver.
So that enzyme is necessary in our liver for our liver to make cholesterol.
And remember, our liver is making over 50% of the cholesterol floating around in our body, right?
So if you have more HMG-CoA reductase, then you have more cholesterol floating around in your body.
If you reduce that reductase,
That enzyme, then you have less cholesterol.
And Erin, it goes even further than that.
Because what happens is that by blocking this enzyme in particular, because it is the rate limiting step, meaning it's like the slowest one in the daisy chain, right, when you're moving stuff into a house.
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