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James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So even if we rewound the tape of life on Earth, we probably wouldn't get something that looks exactly like what we have today.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And so doing that on a different planet, it's just incredibly unlikely that there wouldn't be some contingencies that pushed life to evolve in a way that's a bit different.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, exactly.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, for sure.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

When I first got involved in this, which was about the middle of 2024, this working group was just starting to form that Jack Szostak and John Glass were co-chairing.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So I worked really closely with them and a few others to basically write up the paper, recruit more people into the working group and think about how we wanted to communicate this to the world.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So we had these meetings with all of these top scientists from China, from Japan, from the US, from Europe, where we'd all be on Zoom calls, kind of going through the arguments, going through the exact recommendations that we wanted to make in the paper.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It was a pretty crazy time.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, I mean, it was really international.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So some of the top synthetic biologists in China were involved in the group.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Someone called Chen Liliu, who is on MBDF's advisory board.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

He runs like a 6,000 person synthetic biology institute.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Hiroaki Suga, who is one of the top synthetic biologists in Japan, who's founded...

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

like big successful companies so this was also a group that is not naive to the potential benefits of new technologies like these people a lot of them have been successful in biotech and are really pushing the frontier of synthetic biology right right were there okay so that was kind of the beginning um were there i don't know particularly big hurdles or particularly big wins from there

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

One thing I'll say is it was quite hard to get 38 people to agree on the exact text that we used in the science paper.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

We literally had these Nobel Prize winners, all these top scientists from all these different countries in a single Google Doc commenting back and forth, arguing about different bits, trying to agree on the text.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So that was pretty fun.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It was definitely a bit intimidating getting introduced to all of them.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

When I first joined, I flew around the US to meet some of the key people like John Glass and David Relman, met them in person, talked about synthetic biology, which honestly I didn't know that much about at all at the time.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

At this stage, I've spent a fair amount of time thinking about this, but I was new to mirror life and I couldn't believe that