Luke O'Neill

speaker

4,575 appearances 24 recordings 2 series first heard Apr 2026 last heard 3d ago

Luke O'Neill’s voice in public audio — every appearance, attributed to the second.

Trend

recordings per month · last 12 months

Recordings per month over the last 12 months — 24 in all, peaking in Jul 2026 with 6.

Appearances

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Show Me the Science with Luke O'Neill · The Science of Morning Sickness · 27 Aug 2026 podcast

Obviously they must have done their market analysis so it was needed, so I'm not trying to blame them in that regard. voice-verified

But still it was a bit of a disaster the delidomite story. voice-verified

Now, where is the breakthrough? voice-verified

Well, there's a thing called GDF fifteen, another horrible mouthful. voice-verified

Relevant for the subject of nausea. voice-verified

A GDF fifteen is a natural hormone, and what they noticed was women with hyperemesis, the the severe vomiting, they have a genetic difference in GDF fifteen. voice-verified

Now that was discovered uh with 23andMe. voice-verified

Now you may have heard of Twenty Three and Me, they're that company. voice-verified

I mean you send off your voice-verified

your DNA or your s cheek swab and they give you all your genetic information. voice-verified

They managed to notice that if women who had also had hyperemesis there was inclined to be a link with a GDF fifteen variant, right? voice-verified

And that was interesting anyway, that was observed in association. voice-verified

But meanwhile, labs working on GDF fifteen, it is implicated in nausea and vomiting. voice-verified

So if you eat a poison, your body makes GDF fifteen, it goes to your brain, voice-verified

triggers vomiting and nausea to get rid of the poison in your body. voice-verified

So if you like it's a natural hormone that gets made in response to poisons. voice-verified

And then lo and behold, if it's overactive and you're pregnant, you might get hyperemesis. voice-verified

So that was a really interesting breakthrough. voice-verified

And then most recently Steve O'Reilly, a good friend of mine, he's in Cambridge. voice-verified

He's a key guy who works on obesity as his area, but he's an endocrinologist. voice-verified

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