Majid Fotuhi, M.D., Ph.D.

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370 appearances 1 recordings 1 series first heard Mar 2026 last heard 1 Mar

Majid Fotuhi, M.D., Ph.D.’s voice in public audio — every appearance, attributed to the second.

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When you combine them,
you can call it a multimodal lifestyle intervention program.
So there are several clinical trials for new Alzheimer's drugs, and there are several clinical trials for multimodal lifestyle interventions, which used the same cognitive measures as the ones that were used for the clinical trials for drugs.
So it was comparing apple to apple.
And what I discovered was that the Alzheimer's drugs were changing.
They were slowing the rate of cognitive decline.
They were just making people decline a little less than they would otherwise.
Whereas the lifestyle interventions actually improved their cognitive functions.
Now, drug companies often talk about how the drugs...
reduced Alzheimer's disease by 27% or 35% in terms of the change in cognitive function.
How much less worse did they get?
It's about 27 to 35%.
When you look at the same calculation for clinical trials of multimodal lifestyle interventions, the improvements are 200% or 400% better.
So the lifestyle interventions are far more effective than these new drugs.
What I believe will happen in the next three to five years is super exciting.
I think that the next generation of drugs will be more effective.
The current generation are like the first generation.
They're just starting to get a hold of it.
And the lifestyle interventions already we know that are powerful, not only to reduce inflammation, increase blood flow, and increasing the rinsing in your brain, but also reduce amyloid and tau.
All those things combined versus these drugs that focus on the plaques and tangles in the brain.
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