Majid Fotuhi, M.D., Ph.D.
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370 appearances
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first heard Mar 2026
last heard 1 Mar
Majid Fotuhi, M.D., Ph.D.’s voice in public audio — every appearance, attributed to the second.
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and there is a panel of different blood tests that people can obtain.
The most accurate and reliable component of that list of biomarkers is the ratio of amyloid beta 42 to 40, that's one number, and the other one is tau.
So for example, you also have blood tests for NFL, neurofibrillary light chain,
and you have another blood test for GFAP.
These other blood tests are non-specific and can be high, for example, in patients with multiple sclerosis or other conditions.
So this dual blood test, the ratio of amyloid beta 42 to 40, as well as tau, are excellent reflections of one component of the super problems.
They can detect the amyloid levels in the brain, and they can detect tau levels in the brain.
What they cannot detect is how much inflammation is in the brain, what's the health and vitality of blood vessels in the brain, and how the resting process in the brain is happening.
There are new brain MRIs that can detect the impairment in the rinsing process.
See, when the rinsing process doesn't happen, the fluid back up, and then there's a space around blood vessels called perivascular space, and they swell.
And so imagine like a straw and then around, like imagine like you're looking at like a watermelon, you cut the watermelon and then you see these little blood vessels, which were for little straws and around them is empty space on an MRI.
these are the swollen perivascular space and those brain MRIs are advancing well and I think they will become available for clinical use in next couple of years.
We can also look at the health of the blood vessels through ultrasound.
The ultrasounds can measure
the velocity of the blood flow, and that too can tell us how well the blood circulation is happening in the brain.
We don't have a good biomarker for inflammation in the brain, but I can envision that in about two to five years, we'll have a panel of blood tests.
See, if you go see a cardiologist these days and you have chest pain,
they will probably do a stress test, which is to see if you run fast, whether it will be EKG changes, whether there are electrical changes in your heart.
You may get an echocardiogram to look at the pulsation of your heart.
And then you make an angiography, which would look at the blood flow inside the arteries of your heart.
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