Mark Sisson
speaker
665 appearances
2 recordings
2 series
first heard Sep 2025
last heard 17 Apr
Mark Sisson’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Apr 2026 with 1.
Appearances
It's such a controversial topic, Megan.
I think we have a lot of unanswered questions.
Though Western medicine and mainstream lipidology makes it seem like this is a case closed.
Like you said, statin should be in the drinking water.
When you look at the evidence and when you look at some really interesting recent studies, there are some really profound questions about how cholesterol affects the risk of human cardiovascular disease in certain contexts.
And what I mean by that is when I think about cholesterol as a doctor, I'm thinking about it in the context of your metabolic health rather than just looking at your cholesterol numbers in the vacuum.
And I've seen this over and over, whether I'm reading posts on X, I find these anecdotes on X particularly interesting.
And I see this over and over.
People will say, my doctor missed a heart attack.
My cholesterol was actually normal.
So your LDL level on these people was normal, but the doctors didn't check.
blood markers that can easily indicate metabolic health or lack thereof, things like a fasting insulin.
Most doctors will look at things like a fasting glucose or a hemoglobin A1C, which are just blood markers.
But a lot of the doctors don't think about the overall context of your metabolic health, even looking at thyroid hormone markers when they're evaluating your lipids.
And so it's important, I think, on both sides of the spectrum.
So even at quote unquote low or acceptable levels,
of LDL cholesterol, which is the main molecule that doctors get worried about, we have to be thinking about metabolic health and you can miss cardiovascular risk if you're not looking at things like thyroid labs and fasting insulin, fasting glucose, hemoglobin A1C.
And then at the other end also, a lot of us, I think if we're eating reasonable amounts of animal foods, which I will talk about this in this show today, I think are very important for humans, we might see the LDL cholesterol go above levels that most doctors would like it to be under.
For instance, my LDL cholesterol is probably around 120 or 130 milligrams per deciliter.
But I think that we have a long way before we can fully say that this represents an increased risk of cardiovascular disease for humans, especially without the context of your metabolic health.
Showing 1–20 of 665 · page 1 of 34
Next →