Mark Sisson
speaker
665 appearances
2 recordings
2 series
first heard Sep 2025
last heard 17 Apr
Mark Sisson’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Apr 2026 with 1.
Appearances
There's no such thing.
Obesity is very complex.
And certainly I think there are some people who are predisposed to gaining weight more quickly than other people.
We see this across genetic lineages.
I mean, I went to medical school in Tucson, Arizona, and this is a fascinating story.
So there's a group of Native Americans that are called the Pima Indians.
And the Pima Indians are today the most obese and the most diabetic population ever.
On the face of the earth, 70 to 80% of people in the Pima Indian population are obese and about the same number have diabetes.
So we're talking, you know, you can fact check me on those numbers, but we're talking 50 to 70 plus percent of people in a population that have diabetes and the majority of them are obese.
But what's fascinating is if you look up pictures of Pima Indians from 200 years ago, they were skinny.
they had six packs.
They were not obese.
And so we don't have genetics changing in 200 years.
We have a food landscape changing massively.
And so that's interesting.
So if we want to have a candid conversation about these GLPs, this wide variety of triple, double, and single agonists for weight loss, we also need to have a conversation about what's causing the obesity in the first place, because that I think is the most fascinating thing
that's coming out of this for me.
I mean, there are populations like the Pima Indian all over the place.
200 years ago, the population is fit and they're obese today.
So what's changed?
Showing 341–360 of 665 · page 18 of 34
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