Michael Burke

speaker

505 appearances 4 recordings 4 series first heard Aug 2011 last heard 7 Jul

Michael Burke’s voice in public audio — every appearance, attributed to the second.

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All In The Mind · An inflammatory story: Depression and immunity · 20 Aug 2011 podcast

And it can launch what we call a cell-mediated immunity where particular cells, like creatively called natural killer cells, somebody should make a movie on them, launch an attack against the invading microbe.

And the body launches a host of chemical combatants in this war against microbes.

Absolutely, cascade of immune cells and an orchestra of immune proteins and factors that are part of this very sophisticated response.

There are human studies as well where people are given interleukins, and these are probably the single best models in humans we've got of the induction of depression.

We've just done some epidemiological research where we looked at people in the general community who've never before been depressed, and we measured their cytokines.

And what we showed was those people who had the highest levels of cytokines, even though they'd never before had any psychiatric illness, they had by far the greatest risk of developing depression over the next 10 years.

it?

So this is a wonderful epidemiological study, initially begun in osteoporosis, but it's got the kind of data that allows us to look at all kinds of fascinating things.

For example, the relationship between immunity and risk for illness.

We're trying to get an understanding of what are the biological processes that increase one's risk of developing depression.

And at the same time, get a handle on what are those factors that might link to inflammation itself.

And can we do something about it to try and help people who have the difficulties or even better, prevent them in the first place?

So we're very interested in what might be reversible factors that contribute to inflammation.

And what's particularly interesting is that a lot of lifestyle factors seem to play a role in risk for depression.

And many of these lifestyle factors have very important effects on immunity.

So, for example, we know that diet influences one's risk for depression.

So people who have the best quality diets have the lowest risk of developing depression.

We also know that diet affects immunity.

Similarly, we know that people who are the most physically active seem to have the lowest risks of developing depression.

Again, this ties to immunity.

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