Michael Burke

speaker

505 appearances 4 recordings 4 series first heard Aug 2011 last heard 7 Jul

Michael Burke’s voice in public audio — every appearance, attributed to the second.

Trend

recordings per month · last 12 months

Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

newest first · ▶ plays the moment

All In The Mind · An inflammatory story: Depression and immunity · 20 Aug 2011 podcast

So now you're getting the beginnings of a vicious cycle.

So you're getting damage to the very components of the brain that are responsible for the modulation of mood.

And this further increases your vulnerability to depression.

And it fits very much with the whole idea of staging and the early intervention idea that you've got this cascade of events.

We call it neuro progression whereby you have this inflammatory and oxidative insult damaging the brain.

These insults actually consume nutrients like fatty acids.

which are already depleted, but you become more depleted.

So you become more depleted in many of these nutrients, zinc, magnesium, fatty acids.

There's further damage to the structures that modulate mood.

This increases your vulnerability to get depressed again and may actually...

vicious

Correct.

Well, that's fascinating.

And it's probably because these chemicals have more than one function.

In the periphery, they have very important functions in terms of fighting bugs.

But in the brain, they have very important functions in cellular signaling.

Many of these cytokines actually modulate the signaling between elements of the brain.

Inflammation changes the signaling cascades.

Many of the transmitters

The neurotransmitters

Showing 441–460 of 505 · page 23 of 26