Michael Regilio
speaker
2,071 appearances
9 recordings
1 series
first heard Nov 2024
last heard 12 Jul
Michael Regilio’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Jul 2026 with 1.
Appearances
And products like lattes and teas and whatever you're giving your dog that you buy at the store, those tend to have around 20 grams or so. So are the effects mostly psychosomatic, like placebo kind of thing? Essentially, that's what my research showed. But I've had a few and it feels like it's more than psychosomatic.
But the point is our bodies and our brains already have the receptors in place to interact with cannabinoids. The thing is, cannabinoids like THC are way more powerful than the ones our bodies make. Thousandfold more powerful. When consumed, psychoactive components are absorbed into the bloodstream and cross the blood-brain barrier.
These effects are quick, way quicker than, say, drinking a scotch and soda. Cannabis, when smoked, enters the brain within 30 seconds.
Actually, that's interesting you say that because what kind of high you experience depends on the strain of cannabis you've taken.
You're referring to indica and sativa? Yes, of course I am. And you are right. The two main strands of cannabis are sativa and indica. There's actually also a strain called ruderalis, but it's so seldomly used that we're just going to skip it. Sativa and indica give different highs because they interact with our brains differently. Let's start with sativa.
Sativa plants are taller than indica and have longer leaves. Sativa is considered more of a stimulant. Users feel more alert and focused when on it compared to indica. Sativa is a mood elevator and makes people talkative, and some call it a head high. Sativa does this because it's activating receptors in the prefrontal cortex of the brain. Sativa can reduce stress.
It is believed to have some pain management properties and gives users a heightened sense of importance towards their activities.
I don't get it. There's head high and then there's body high. Indica is considered a body high. It relaxes you physically. That's why it's colloquially called Indicouch. Indica is more of a sedative. This is because Indica suppresses the amygdala part of the brain and also shuts down the hippocampus. The indica variety of cannabis can lead to defects in memory.
Indica is often used for sleep disorders and anxiety relief.
Not anymore, in fact. because it's actually pretty rare to find pure sativa or indica these days. We live in the age of hybrids. Through plant genetics, growers have souped up that boring old cannabis and crossed sativa and indica into many hybrids that have qualities of both plants.
Yeah, and the different strains do have different effects, but it's possible that marijuana in general is just not for you. But while we're talking about the genetic manipulation of cannabis, it's worth mentioning that they've also souped up the amount of THC, and that might be what's freaking you out.
Whereas the THC and the cannabis we discussed at the top of the show might have been around the low single digits. Modern cannabis is over 20 and 30 percent THC.
No, look, my father's pot was kept in a coffee can above the fridge and was loaded with seeds and stems. He was getting hosed by his dealer for sure. But as far as modern pot goes, growers have gotten so good at manipulating the plants that there are all new categories of hybrids, type 1, type 2, and type 3. Okay, so what do those types mean? I've never heard of this.
Those refer to the THC to CBD ratio. Type 1 has the most THC and a little CBD. Type 2 has less THC and more CBD. And type 3 has very little THC, mostly CBD.
OK, so CBD, just like THC, is a cannabinoid. Only CBD doesn't get you high, but has other distinct effects. Many believe CBD has many great medical uses.
OK, let me start by saying that there is a very effective seizure medicine on the market today that is derived from CBD. So, yes, CBD has medical merit. But according to Margaret Haney, Ph.D., professor of neurobiology at Columbia University Medical Center and leading cannabis researcher, the claims are quickly outpaced by the research because cannabis is still a schedule one drug, though.
This stuff is actually really hard to study.
Well, I mean, most medicinal claims aren't always backed up with hard data. Plus, most of this stuff is just subjective. As we talked about, the placebo effect. If you think it's helping you sleep, it helps you sleep. If you think it's calming you down, it calms you down. If you think it's helping you write good poetry...
Placebo can't help you there. Okay, fine. That part is true, but nothing can help you there. True. But the fact remains that we're in the realm of the brain-body connection, and it's the intersection of things we still have a lot to understand. It's still a murky area for medical science. Let's list a few proven positives of cannabis and CBD.
There's firm evidence suggesting cannabis treats the side effects of chemotherapy, multiple sclerosis, spasticity, chronic pain, sleep disorders, neuropathy, appetite loss, and inflammation.
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