Mike Israetel
๐ค PersonAppearances Over Time
Podcast Appearances
And then the fourth group, they gave him the activin alpha, the activin A inhibitor, myostatin inhibitor plus semaglutide. So three fucking vectors. And what they found was the group number one, the natty monkeys, they lost almost no muscle and they lost a bit of fat. Group 2, the semaglutide monkeys, lost almost double the fat, but a significantly more muscle. Not a ton, but you can tell.
And then the fourth group, they gave him the activin alpha, the activin A inhibitor, myostatin inhibitor plus semaglutide. So three fucking vectors. And what they found was the group number one, the natty monkeys, they lost almost no muscle and they lost a bit of fat. Group 2, the semaglutide monkeys, lost almost double the fat, but a significantly more muscle. Not a ton, but you can tell.
Group 3, that had the myostatin drug plus semaglutide, lost almost double the fat that the semaglutide monkeys lost. Almost triple the fat that the natty monkeys lost. And they lost about the same amount of muscle as the monkeys who were natty, which is to say almost none. So we're talking about a drug that you can lose like 2.7 times X the fat, but with zero added muscle loss. Check this out.
Group 3, that had the myostatin drug plus semaglutide, lost almost double the fat that the semaglutide monkeys lost. Almost triple the fat that the natty monkeys lost. And they lost about the same amount of muscle as the monkeys who were natty, which is to say almost none. So we're talking about a drug that you can lose like 2.7 times X the fat, but with zero added muscle loss. Check this out.
Group 3, that had the myostatin drug plus semaglutide, lost almost double the fat that the semaglutide monkeys lost. Almost triple the fat that the natty monkeys lost. And they lost about the same amount of muscle as the monkeys who were natty, which is to say almost none. So we're talking about a drug that you can lose like 2.7 times X the fat, but with zero added muscle loss. Check this out.
The triple monkeys, myostatin, activin, and semaglutide, they lost even more weight by a little bit. So basically three times the weight that the natty monkeys lost in fat. And they gained in muscle at the same time what the drug-free monkeys lost in fat. Wow. Wow. Wow. So let me put this really quick into common terms.
The triple monkeys, myostatin, activin, and semaglutide, they lost even more weight by a little bit. So basically three times the weight that the natty monkeys lost in fat. And they gained in muscle at the same time what the drug-free monkeys lost in fat. Wow. Wow. Wow. So let me put this really quick into common terms.
The triple monkeys, myostatin, activin, and semaglutide, they lost even more weight by a little bit. So basically three times the weight that the natty monkeys lost in fat. And they gained in muscle at the same time what the drug-free monkeys lost in fat. Wow. Wow. Wow. So let me put this really quick into common terms.
I translated these numbers into proxy for like a 200-pound person at 20% body fat. If the results hold for humans, which they'll similarly hold for humans, especially if you adjust the dosing. The natty human would be like two identical twins, one twin, 20% body fat. After 20 weeks, he's going to weigh 200 pounds, 20% body fat.
I translated these numbers into proxy for like a 200-pound person at 20% body fat. If the results hold for humans, which they'll similarly hold for humans, especially if you adjust the dosing. The natty human would be like two identical twins, one twin, 20% body fat. After 20 weeks, he's going to weigh 200 pounds, 20% body fat.
I translated these numbers into proxy for like a 200-pound person at 20% body fat. If the results hold for humans, which they'll similarly hold for humans, especially if you adjust the dosing. The natty human would be like two identical twins, one twin, 20% body fat. After 20 weeks, he's going to weigh 200 pounds, 20% body fat.
He's going to weigh about 192 pounds at about 16.5% fat, 20 weeks of dieting, drug-free. Cool, right? Cool. That's good. That's good, right? Janice at work notices and tries to suck your dick in the bathroom as usual. Yeah. And then, but you're at work. Janice, get the fuck away from me. I got shit to do.
He's going to weigh about 192 pounds at about 16.5% fat, 20 weeks of dieting, drug-free. Cool, right? Cool. That's good. That's good, right? Janice at work notices and tries to suck your dick in the bathroom as usual. Yeah. And then, but you're at work. Janice, get the fuck away from me. I got shit to do.
He's going to weigh about 192 pounds at about 16.5% fat, 20 weeks of dieting, drug-free. Cool, right? Cool. That's good. That's good, right? Janice at work notices and tries to suck your dick in the bathroom as usual. Yeah. And then, but you're at work. Janice, get the fuck away from me. I got shit to do.
And then the other identical twin, in this case, with the three drugs, started at 200 pounds, 20% body fat, in 20 weeks would have gotten to 181 pounds, which, okay, he lost like 10 more pounds, 11 more pounds, cool. 6.5% body fat. Wow. Wow. You guys, this is coming. Wow. It is only one of the drugs that Regeneron Pharmaceuticals is working on. It's already a drug. They already know it works.
And then the other identical twin, in this case, with the three drugs, started at 200 pounds, 20% body fat, in 20 weeks would have gotten to 181 pounds, which, okay, he lost like 10 more pounds, 11 more pounds, cool. 6.5% body fat. Wow. Wow. You guys, this is coming. Wow. It is only one of the drugs that Regeneron Pharmaceuticals is working on. It's already a drug. They already know it works.
And then the other identical twin, in this case, with the three drugs, started at 200 pounds, 20% body fat, in 20 weeks would have gotten to 181 pounds, which, okay, he lost like 10 more pounds, 11 more pounds, cool. 6.5% body fat. Wow. Wow. You guys, this is coming. Wow. It is only one of the drugs that Regeneron Pharmaceuticals is working on. It's already a drug. They already know it works.
It just has to go through FDA trials and don't you fucking bet against this. All the other pharmaceutical companies are catching on to that shit too because they realized semaglutide and all the GLP-1s and the GIP drugs that they have out now, they're unbelievable at helping people lose weight. The problem is people in a huge caloric deficit like that will lose some muscle.
It just has to go through FDA trials and don't you fucking bet against this. All the other pharmaceutical companies are catching on to that shit too because they realized semaglutide and all the GLP-1s and the GIP drugs that they have out now, they're unbelievable at helping people lose weight. The problem is people in a huge caloric deficit like that will lose some muscle.
It just has to go through FDA trials and don't you fucking bet against this. All the other pharmaceutical companies are catching on to that shit too because they realized semaglutide and all the GLP-1s and the GIP drugs that they have out now, they're unbelievable at helping people lose weight. The problem is people in a huge caloric deficit like that will lose some muscle.