Nick Miles
speaker
3,281 appearances
60 recordings
3 series
first heard Dec 2024
last heard 2 Sep
Nick Miles’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 18 in all, peaking in Jun 2026 with 9.
Appearances
Now, though, there has been a significant breakthrough.
Results of a clinical trial of a daily pill for patients in advanced stages of the disease show that it can double the survival time and has fewer side effects than chemotherapy.
Dr Emil Liu is an oncologist at the University of Minnesota in the US.
He's been speaking to James Menendez.
this clinical trial evaluated patients who had received treatment for metastatic stage four forms of pancreas cancer, received at least one form of therapy that no longer worked.
But for the results to be as impactful as they are in that setting, when patients have previously received chemotherapy, often treatments don't work more than just a few months.
But in this case, it exceeded one year.
In layman's terms, how does it work then?
It's kind of like an out-of-control car where the accelerator is constantly on and you can't put on the brakes.
We're trying to slow down the car and drive it maybe at the speed limit.
KRAS is the signal.
It drives more than 20% of all cancers, more than 90% of all pancreas cancers, and it's been very elusive as a drug target.
Now the drugs hit the target, and this is important because it helps to slow down the car, so to speak.
In this clinical trial, approximately 250 patients who received the drug exceeded one year in terms of their survival, nearly 13 months.
And that's about six and a half months longer than patients who received standard of care chemotherapy alone.
So it slows down the spread of the cancer.
And you mentioned that this KRAS is present in other forms of cancer.
Does this mean that this drug might be used to treat those too?
Absolutely.
And I know clinical trials are underway and I think are going to expand at a very accelerated pace in the weeks and months and years to come.
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