Prof Tim Spector
speaker
2,014 appearances
16 recordings
2 series
first heard Apr 2026
last heard 5d ago
Prof Tim Spector’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 16 in all, peaking in Sep 2026 with 4.
Appearances
I think it's a really serious topic because every person with a brain disorder, I prefer to call them brain disorders than separate mental health from degenerative brain health.
It's all the same organ.
And really, there isn't really a separation between mind and body.
It's just another organ that's going wrong.
In every condition studied, there's an abnormality in the gut microbiome when you compare...
cases with the disease and controls without it so everything that goes from dementia alzheimer's parkinson's disease all the way through to autism to schizophrenia to depression anxiety ptsd obsessional disorders everything
something's going on in the gut microbiome now that's association it doesn't necessarily mean it's causation and it's quite hard to do those studies because you'd have to test someone and then wait 10 years in a cohort to do that and the field is too young so we have to rely on mouse studies to really show us what's going on i don't do mouse experiments but i have to read about them and
these mouse studies are really good at showing mechanisms are possible.
Obviously, humans are not mice, but really clever experiments have taken transplants from one mouse to another.
You take an anxious mouse, you take their poo, you transplant it into a germ-free sterile mouse, you can make that mouse anxious.
And by using antibiotics and things, you can reverse that process.
There are also some experiments where they've put stool samples from humans with depression or anxiety, and they've transplanted sterile mice with them, and they've reproduced those symptoms.
And they've also done that for other mental health disorders like psychosis and schizophrenia.
So there really is pretty good evidence that there is a link between the two.
There are also really interesting links in brain diseases like Parkinson's, which is a shaking palsy, but it's associated with dementia.
And that's really increasing at the moment.
And when they look back,
At their history, they find that 10 years before, the majority of people who develop these brain symptoms had really bad constipation and gut problems.
And they're finding that the gut microbiome in those people was abnormal 10 years before and had proteins that were being formed because there was inflammation in the gut microbiome.
And we think the link is...
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