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Shana Kelley

👤 Person
179 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Yeah, absolutely.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

You described it very well that for the chronic diseases that are hard to manage, right?

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Heart failure is a classic.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

You know this better than me that, you know, you have patients in various stages of heart failure and they may be okay and they seem to be, you know, at a steady state.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

But then something happens and they wake up and their ankles are swollen and it's not clear what's going on.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Do medications need to be titrated?

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

You know, if you could see what BNP had been doing over the last 24 to 48 hours, that would probably give you an answer in terms of what action to take next.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

So I think chronic disease management is absolutely a place that we can just do so much more for patients if we're able to monitor them properly.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

septic patients in the ICU, right?

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Really understanding what inflammation, how it's trending there.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And then you mentioned neurodegenerative disease.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

I mean, one of the things that I think is really fascinating to think about as an application, maybe not in humans, but in our model organisms, just really understanding neuroinflammation and what happens in the brain, you know, when you have a spike in inflammation, right?

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

There are people that are diagnosed as being schizophrenic

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

But they actually just have inflammation in their brains.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

And when they're treated appropriately, right, the psychosis goes away.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

But we really, it's very much a black box.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

So I think we can do a lot for patients if we can take the technology where I would like to.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

But we can also answer a lot of questions about how inflammation affects us systemically, but also at the organ level.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

Yeah, so that's actually the hard part.

Ground Truths
Shana Kelley: Biosensors to Track Proteins and Inflammation in Our Blood in Real Time

I mean, the inventing and the proof of concept and all, that was hard.