Tina Moore
speaker
1,621 appearances
16 recordings
2 series
first heard Jan 2025
last heard May 2025
Tina Moore’s voice in public audio — every appearance, attributed to the second.
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And trizepatide decreased participants' calorie intake at lunch and dinner by reducing appetite. So here's what the obesity docs online had to say about it. They said, you know, we're hearing our patients tell us that they're taking trizepatide and...
that even though they're not changing their caloric intake, meaning they're not decreasing their calories, they're still losing weight, is there some magic way that this peptide is working? And these obesity docs concluded from this paper of 55 people that no, there's no magical metabolic impact. It's literally calories in, calories out.
It's due to the caloric restriction is why they are losing weight because of this peptide. Highlight here, which I already read, turns appetite decrease participants' calorie intake at lunch and dinner by reducing appetite.
belief out there is that calories in calories out is the holy grail and i'm not saying that these docs believe that only but that's the going belief in the world and that these peptides only work by reducing calories that they're self-starvation peptides and because you eat less you lose weight and that's it end of story case closed
If you've been listening to me for any appreciable amount of time, you know that's completely untrue. They work on your metabolism in a multitude of ways. Most notably, they decrease inflammation in the body. They improve insulin signaling on both sides, insulin production, insulin reception. They increase the AMPK pathway.
They stoke it, which is going to help with mitochondrial health, which is ultimately going to translate into metabolic health improvements. So we've got a lot of different mechanisms at play. There's more than this. You know, there's impacts on the brain. There's a decrease of inflammation in the brain. There's various mechanisms by which GLP-1s impart themselves on your metabolic health overall.
It's not just about calories in, calories out. But they looked at the study and they decided that because there was no metabolic adaptation change in humans, even though there wasn't mice, that therefore no metabolic impact. It truly is a calories in, calories out thing. That said, they're still amazing peptides. I wanna break down what all this means because I think they're wrong.
I think there is a very protective mechanism on the metabolism going on here. And I wanna explain to you what these terms mean and how this works so that you understand that I think this paper actually proves that they have a really profound impact on our metabolic health overall beyond what caloric restriction would do on its own.
Okay, so to truly understand this paper, we first have to get some terms out of the way and we have to understand what they mean. I want to explain what metabolic rate is, what resting metabolic rate is in the first place. So this is the number of calories that your body burns at rest just to keep you alive. That's your resting metabolic rate, all right?
This is your breathing, your heartbeat, your blood pumping, all of it, digestion, et cetera. Your resting metabolic rate, RMR, is what we're going to call it, is largely driven by your lean body mass and to a lesser extent by your fat mass. This is why I'm always banging the drum that you have to lift weights, that it's non-negotiable.
Because when you lift weight and you add muscle to your body, you increase your resting metabolic rate, which means you get to eat more. You burn more calories just sitting around on your ass than you would otherwise. So we lift weights so that we can sit on our ass when we want to and not worry about it. You don't get to sit on your ass and do nothing if you're not lifting weights.
that just turns you into a blob, a metabolically busted blob, which is what most of this country is, and that's not helping anything. So no disrespect, but most people are going from bed to the couch, to their car, to their desk, back to their car, back to their couch, back to their bed. It's no wonder why 94% of U.S. adults are metabolically compromised.
So what should happen when you lose weight, if you lose weight, especially fat and muscle, because anytime we caloric restrict, we're going to lose some muscle, your body needs less fuel to operate. This is why it's really problematic when people lose weight. It's so difficult to keep it off and why the success rate of that is so low.
It's because as you decrease your body size, you decrease your body mass, your body needs less fuel to operate. So your resting metabolic rate is going to go down. No matter what, no matter how you lose the weight, you are going to have some reduction in your resting metabolic rate. And that is going to cause problems in that now you have to eat less to maintain that size.
This is the cycle and loop that folks with obesity get trapped in because they lose 100 pounds, let's say, or they lose 50 pounds or they lose 25 pounds. And now their resting metabolic rate has gone down. So it's going to take more exercise and less food to maintain what they just achieved. This is not an absolute true statement, but this is what I hear folks struggling with obesity say.
It was almost easier before I lost the weight. At least I could maintain that set rate, right? And I didn't have to fight so hard to hold it. But once you lose weight, any of you who've lost any appreciable weight know to hold on to that weight loss, to hold on to where you've dropped to is really difficult to maintain.
So the way that I explain this to folks is if you ran four miles a day to lose five pounds, once you've lost it, you have to now run five miles a day to maintain it or you have to eat much less. All right. So this is the expected resting metabolic rate drop. This is what metabolic adaptation is. It's, it's,
the body going into starvation mode and trying to desperately hold on to what it has, because you've just taken away a bunch of mass if you've lost weight and your body is like, oh no, we must go into starvation mode, that's metabolic adaptation.
We don't really want metabolic adaptation to go up, meaning the more that we have a metabolic adaptation, the more of a starvation mode we've gone into, okay? So when you lose weight, there is an expected resting metabolic rate drop. But what sometimes actually happens, and they figured this out with a couple studies years back, most notably the Biggest Loser Study.
I'll go through that in a bit, the Biggest Loser Study, and I'll explain what happened. But what sometimes happens is when you have a crash diet or you have a significant amount of weight loss in a short amount of time, you get an actual rate
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