306. The Alzheimer's Drug With a 25% Brain Bleed Risk - Dr. David Perlmutter
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What early metabolic factors increase Alzheimer’s risk?
Alzheimer's is an almost uniformly fatal condition. The third leading cause of death in adults in America.
You know, there's a lot of theories around Alzheimer's and accelerated brain aging, but many of them point to insulin resistance and high blood sugar as one of the hallmarks of accelerated neurocarpia.
Cognitive decline. 90% of America's prediabetic patients don't know it. Because you get your annual blood work, you get a pat on the back. Well, you're not diabetic yet. Go home and hope for the best. I really reject that in the face of 7.6 million Americans now diagnosed with Alzheimer's, with being pre-diabetic being a huge entree to that.
That event. I think there are a lot of people that my age that are dealing with aging parents, and I'm hell bent on turning this around for my mother, and to the extent that I can prevent it for other folks like my kids. That's a service that I think is well met.
I'm hell bent on getting this message out that you could rewrite your destiny as it relates to your brain, and you absolutely can do it, and you just need the tools. In these conditions.
Like Alzheimer's. Patients are not losing their memory per se. They're losing access to their memory. What do we do now to try to restore that access?
You know, ultimately I think well beyond what I describe here is
He wins.
Hey guys, welcome back to the Ultimate Human Podcast. I'm your host, human biologist Gary Brecker, where we go down the road of everything, anti-aging, biohacking, longevity, and everything in between. And today's podcast guest is a very, very, very special guest to me. He doesn't even realize this, but In the 300 plus episodes that we've done on the ultimate human, only one other time have I used this next phrase that I am sitting down with someone that I consider one of my early mentors in this space. Uh, the first time I used that was with um uh Mark Hyman, because I had read most of his New York Times bestselling books. And in 2014, I read a book that this gentleman authored called Great. Brain brain.
And it entirely and permanently changed the trajectory of my career. So Dr. David Pearl Mutter, welcome to the Well, I'm
delighted to be here today. It's uh very special to be here too. I love this area of the world. Very has a lot of meaning for me.
Yeah, you know, we I I learned something very special before the podcast today. I walked into my kitchen and he was FaceTiming with my father in law. And it turns out that my wife's father built your dock forty years ago. That's right. That's a wild uh connection that we have, but uh the work here has been enabled. It's a small world though. I mean, who knew? It's a small world. But um I read Grain Brain. I I wanna say you wrote it in two thousand thirteen, but I read it in two thousand fourteen. So uh yeah.
It was published in two thousand thirteen, wrote it in two thousand twelve, obviously. And you know, that book focused, I think, on something that's now pretty well understood and embraced, that eating a diet that features a lot of highly processed carbohydrates is a bad thing for the brain. That was my contention back then. And I you know, it was a a great success the book was a great success, but I got a lot of heat from my colleagues that I mean, what do carbs have to do with the brain? How could you make such a statement? We didn't have the term back then of ultra processed foods. Right. Now of course that's what we're talking about. And ultra processed carbohydrates being under that umbrella. And now we see really great data coming out that higher consumption.
Of these foods that are modified such that they're going to raise your blood sugar, threaten the functionality of your insulin, and at the same time are devoid of things that you need, like dietary fiber to nurture your microbiome, that these happen to be really threatening for your metabolism. And guess what? The brain is intimately involved with metabolism, either being supportive or being destructive.
And you know, I I'm I'm going through this right now. I've been very public about this on my platform with with my own mother.
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Chapters
8 chapters
1
What early metabolic factors increase Alzheimer’s risk?
0:00–13:52
2
How does pre‑diabetes lead to type 3 diabetes and brain decline?
13:52–25:36
3
What role do APOE4 and microglial cell shifts play in Alzheimer’s?
25:36–37:13
4
How can inflammation from gut, mouth, and air accelerate neurodegeneration?
37:13–49:50
5
What exercise regimen (aerobic vs resistance) best protects the brain?
49:50–1:02:19
6
How do the Tanzi‑Ornish trials and the POINTER study show lifestyle can reverse decline?
1:02:19–1:15:10
7
Why do beta‑amyloid drugs carry a 25 % brain‑bleed risk and what does the data say?
1:15:10–1:25:24
8
Which supplements (creatine, vitamin D, DHA, B‑complex) truly support brain health?
1:25:24–1:36:57
Speakers
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