paroxanthine in Podcasts
productParoxanthine, a primary metabolite of caffeine, acts as an adenosine receptor antagonist and influences stimulant effects.
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Paroxanthine supplements.
Since paroxanthine is by far the dominant primary metabolite, and its further metabolites are mostly either very short-lived or have poor affinity for adenosine receptors, we can fruitfully use a simplified model of caffeine-paroxanthine elimination.
Paroxanthine then has its own 3-5 hour half-life as it's metabolized into a handful of other things.
In particular, more than 80% of circulating caffeine is metabolized into paroxanthine, which has a comparable binding affinity at adenosine receptors to caffeine itself.
Paroxanthine is sort of like caffeine that behaves the way many mistakenly believe caffeine behaves.
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