paroxanthine
product
5 mentions
2 recordings
first heard Mar 2026
last heard 9 Apr
↑5 vs the 12 months before
Paroxanthine, a primary metabolite of caffeine, acts as an adenosine receptor antagonist and influences stimulant effects.
Trend
Peak in the week of 7 Apr — 4 mentions across 1 series.
Moments
newest first · ▶ plays the momentUnknownLessWrong (Curated & Popular) · "The effects of caffeine consumption do not decay with a ~5 ... · 1:46 · 9 Apr
…Since paroxanthine is by far the dominant primary metabolite, and its further metabolites are mostly either very short-lived or have poor affinity for adenosine receptors, we can fruitfully use a simplified model of caffeine-paroxanthine elimination.…
UnknownLessWrong (Curated & Popular) · "The effects of caffeine consumption do not decay with a ~5 ... · 1:39 · 9 Apr
…Paroxanthine then has its own 3-5 hour half-life as it's metabolized into a handful of other things.…
UnknownLessWrong (Curated & Popular) · "The effects of caffeine consumption do not decay with a ~5 ... · 1:29 · 9 Apr
…In particular, more than 80% of circulating caffeine is metabolized into paroxanthine, which has a comparable binding affinity at adenosine receptors to caffeine itself.…
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