Dr. Chantelle Thomas
speaker
1,116 appearances
2 recordings
1 series
first heard Jul 2026
last heard 30 Jul
Dr. Chantelle Thomas’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 2.
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Um, it's actually a selective glutamate antagonist agonist.
So it actually works at one of the glutamate sites to block and one to shunt more glutamate to other neurotransmitters.
The reason why that's important is because many of the drugs that we've looked at for improving mood focus on serotonin, and this one focuses on glutamate.
And actually, up to 80%, and don't quote me on that, of the neurochemic.
chemical signaling that happens in the brain involves glutamate and um GAB is the opposing neurotransmitter.
So there's actually a lot of real estate that's very valuable to kind of work with when you're working with a compound like ketamine.
Like I mentioned before, it's an anesthetic dissociative, is the original classification.
That's because in medical settings, ketamine is actually used for sedation procedures.
Um, it's been deemed one of the essential medicines by the World Health Organization.
It was first used on the army lines in Vietnam to sedate soldiers safely without dropping their vitals to do procedures.
So it has analgesic properties, it has sedative properties.
And then it has this quite miraculous and robust antidepressant effect as a result of the chemical downstream pathway, which involves a number of things, including mTOR, and then something called brain-derived neurotropic factor, which suggests that it can actually produce neurogenesis.
So
neuronal regrowth or dendritic regrowth under certain
Powell Well I think it it's considered by many who know about it to be um an unprecedented uh compound for depression because many of the
the psychotropics that we have for depression take two to four to six weeks.
I mean, I would say four to six and in some instances eight weeks before you're gonna start to see an impact.
If
If you're going to see an impact.
And also the mechanism is very different because for whatever reason, it seems like the whole class of psychedelics, you're not getting this clipping of the affective range that you get with some of the SSRIs.
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