Dr. Craig Koniver
speaker
302 appearances
1 recordings
1 series
first heard Oct 2024
last heard Oct 2024
Dr. Craig Koniver’s voice in public audio — every appearance, attributed to the second.
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You know, people don't always get there as quickly, but people get there with their sleep. Love it. And you compound it with glycine? Yeah. What's the rationale there? I really like glycine as an inhibitory neurotransmitter. It's calming to the nervous system over the years. I tend to start with that when people are having trouble settling down at night.
Not that it's going to sedate people, but just transitioning from being active. You know, 8 p.m., 9 p.m., wanting to settle down, glycine in pretty large dosages, at least most people think they are, starting with 3,000 or 5,000 milligrams orally, kind of tones down the nervous system. People relax a little bit, and then they tend to sleep better from it. And then you can dial it up.
Mold's become super big. Yeah, big. Yeah, I mean, it's very prevalent and it seems the more we talk about it, I mean, we've seen it for years and years and years. It makes sense, right? Like if you think about the amount of airplanes flying above us every day, pouring down heavy metals. I mean, it's massive. It's in the air, it's in the water, it's in the soil.
You talk about glyphosate or Roundup, same exact thing. So many chemicals and it's challenging for us as humans. The way I break it down, not to get too far off topic, is we're water-soluble organisms living in a fat-soluble world. It's the job of our liver
essentially to take the fat soluble stuff make it water soluble so we can excrete it right and that takes place in the liver in two phases phase one we're using the p450 enzymes like taking the trash putting the trash in the trash can putting out the side of the road you have phase two amino acid conjugation the trash truck comes and picks up the trash very few things in nature induce phase two independent of phase one meaning most of us have trash piled up on the side of our road
Those things are the polyphenols, right? And so things like the blues, the reds, the pigments. That's why it's important to eat a wide variety of colors in your diet. Matcha tea has a very strong inducing effect on phase two liver activity. Is that right? Yeah. I need to develop a taste for matcha. Yeah. I feel like it's kind of grainy. It is, and it's bitter.
But bitter things tend to be, again, helping that phase two. Glutathione helps phase two. We do a lot of that intravenously. And then glycine. is a wonderful agent for inducing phase two independent of phase one. And the trouble is, I don't think people realize, you know, people are told, well, you know, most pharmaceuticals induce a P450 enzyme.
And a misconception is, well, if I'm just inducing one, I'm good. If you induce one, you induce them all. So if you take any pharmaceutical, you're inducing your entire P450 system. You're speeding it up, meaning you're putting more trash out on the side of the road. And if you look at the amount of things we're being exposed to outside of pharmaceuticals, it's mounting. It's crazy.
Yeah, that's what I'm saying. I'm just using that as a metaphor. Yeah, yeah, yeah.
Right. The trash, again, very oversimplification. You need to speed up phase two to get the trash trucks come to pick up the trash so that you can then take that compound and excrete it in your stool, in your urine, your sweat, your breath. I mean, it's the only way it works. It's not complicated per se, but I think there's a lot of misconceptions about it.
They can. Yeah, glycine is absorbed well orally. It has a really sweet taste. It's actually the smallest amino acid. A huge fan of it. We've been using it a long time. You can take big dosages of it. Very sick. Again, my starting dose is usually three to five grams at bedtime. And then the way I do this, recommend it, is try that for a few nights in a row.
You're not noticing a thing, double the dose. Go to 10 grams, literally. Most people at 10 grams of glycine will notice it. And again, it's not going to necessarily make you drowsy. You're not going to be sedated. But your nervous system is going to be toned down a little bit. It's going to help you fall asleep a little bit better.
And then while you sleep, where a lot of this detoxification process starts working, you're going to be more efficient in how your liver works. Everything ties together. Right.
There's these bioregulator peptides, which were developed by this Russian scientist, last name Korvinson, I think. Done a lot of research, actually. There's published research about it. I think Penelon's one of the ones that... They say we'll survive the stomach acid and get through the gut and be absorbed. So I think that's true. We've always used it as injectable.
And I tend to like injectable things for the bioavailability. So yeah, but to your point, I think people can. Those are going to be harder and harder to find, actually. It's probably easier to find an injectable pineal than an oral one.
Yeah. And researching, right. Making sure that what you're taking is, is legit. A lot of illegitimacy out there.
Big money. The concerning part about the GLP-1s is, to me, is what we're starting to see. They've been able to be compounded because there was a shortage. And the way it works with compounding pharmacies is because those are brand – named drugs, and they're not patented for the peptide, right? They're patented for the delivery system, which is the pen, which most people don't realize.
And they've been able to be compounded and then way more affordable because they're compounded. And there is rumors that the pharmaceutical companies now have supply back. They'll come back and they will remove the ability to allow these peptides to be compounded, which means we'll have to stick to traditional dosages and people will lose access because they're going to be way more expensive.
I mean, they are. If your insurance doesn't cover it, $1,500 a month for most people. Very expensive. That's a lot of money. Yeah. For a lot of people, that's rent and more. So I'm hopeful that doesn't happen. But that's in the works. That's in the works. And that would be a huge shame. And again, I'm not a pessimist by any means. I'm a perpetual optimist.
So we'll just make sure that stays this way. But again, if it does happen, we'll get creative and go other routes as well.
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