Dr. Robert Lustig

But, you know, I recognize the problem and, you know, it's not like everybody understands it.

So I do what I can.

Look, I've got two kids, okay?

I want to leave them something good.

And right now I'm just mortified by what we've done to society and to the planet.

So it's my job to try to do what I can to fix it.

Thank you for having me.

Leptin resistance. The inability to see your leptin. The higher your sugar consumption, the more your insulin resistance. The more your insulin resistance, the less well your brain can see its leptin. The less well your brain can see its leptin, the more your brain thinks it's starving. And the more you'll eat those calories.

Leptin resistance. The inability to see your leptin. The higher your sugar consumption, the more your insulin resistance. The more your insulin resistance, the less well your brain can see its leptin. The less well your brain can see its leptin, the more your brain thinks it's starving. And the more you'll eat those calories.

Leptin resistance. The inability to see your leptin. The higher your sugar consumption, the more your insulin resistance. The more your insulin resistance, the less well your brain can see its leptin. The less well your brain can see its leptin, the more your brain thinks it's starving. And the more you'll eat those calories.

So you can get your calories down not by starving yourself, not by dieting and caloric restriction. You can get your calories down by getting rid of the insulin resistance, which means getting rid of the sugar because that's what caused the insulin resistance because it's the fat in your liver that led to the insulin resistance because your pancreas makes insulin to make the liver do its job.

So you can get your calories down not by starving yourself, not by dieting and caloric restriction. You can get your calories down by getting rid of the insulin resistance, which means getting rid of the sugar because that's what caused the insulin resistance because it's the fat in your liver that led to the insulin resistance because your pancreas makes insulin to make the liver do its job.

So you can get your calories down not by starving yourself, not by dieting and caloric restriction. You can get your calories down by getting rid of the insulin resistance, which means getting rid of the sugar because that's what caused the insulin resistance because it's the fat in your liver that led to the insulin resistance because your pancreas makes insulin to make the liver do its job.

And when you've got the fat in your liver that the sugar caused, now your liver doesn't do its job. Now your pancreas has to make extra insulin. Now you've got insulin resistance. Now you've got high insulin levels at the brain. Now your leptin doesn't work. So all those extra calories you're eating is because your brain doesn't see the leptin because of the sugar you ate.

And when you've got the fat in your liver that the sugar caused, now your liver doesn't do its job. Now your pancreas has to make extra insulin. Now you've got insulin resistance. Now you've got high insulin levels at the brain. Now your leptin doesn't work. So all those extra calories you're eating is because your brain doesn't see the leptin because of the sugar you ate.

And when you've got the fat in your liver that the sugar caused, now your liver doesn't do its job. Now your pancreas has to make extra insulin. Now you've got insulin resistance. Now you've got high insulin levels at the brain. Now your leptin doesn't work. So all those extra calories you're eating is because your brain doesn't see the leptin because of the sugar you ate.

Fix the sugar, you'll fix the calories too. But it doesn't work the other way around. So it's not about the calories. And I'll be happy to debate anybody who says it does.

Fix the sugar, you'll fix the calories too. But it doesn't work the other way around. So it's not about the calories. And I'll be happy to debate anybody who says it does.

Fix the sugar, you'll fix the calories too. But it doesn't work the other way around. So it's not about the calories. And I'll be happy to debate anybody who says it does.

So there is a phenomenon, which I think we talked about it the last time I was on the podcast. It's called TOFI, T-O-F-I. Thin on the outside, fat on the inside, real medical term, 1500 Medline citations coined by Dr. Jimmy Bell, neuroimager at University College London. You can be thin sick and you can be fat healthy. 20% of obese people are fat healthy. Now, 80% are fat sick, I agree.