Nick Norwitz
๐ค SpeakerAppearances Over Time
Podcast Appearances
But we can get a little bit more into the model if you want, but the point is the model starts with your metabolism shifting towards lots of fat burning. So if you put carbs back into the system, it puts the brake on the system, or at least takes the foot off the gas pedal, and your LDL should drop. That is the prediction of the model. So it should drop with any carb.
But we can get a little bit more into the model if you want, but the point is the model starts with your metabolism shifting towards lots of fat burning. So if you put carbs back into the system, it puts the brake on the system, or at least takes the foot off the gas pedal, and your LDL should drop. That is the prediction of the model. So it should drop with any carb.
The fact of the matter is, even before I did the Oreo experiment, we had used sweet potatoes in patients. There are case reports on this, or fruit, or starches. It just wasn't sexy enough to catch headlines. So I'm like, what is? And I'm like, Oreo cookies, that should do it. So I did a rigorous controlled experiment with my locked in baseline diet, a pure addition.
The fact of the matter is, even before I did the Oreo experiment, we had used sweet potatoes in patients. There are case reports on this, or fruit, or starches. It just wasn't sexy enough to catch headlines. So I'm like, what is? And I'm like, Oreo cookies, that should do it. So I did a rigorous controlled experiment with my locked in baseline diet, a pure addition.
The fact of the matter is, even before I did the Oreo experiment, we had used sweet potatoes in patients. There are case reports on this, or fruit, or starches. It just wasn't sexy enough to catch headlines. So I'm like, what is? And I'm like, Oreo cookies, that should do it. So I did a rigorous controlled experiment with my locked in baseline diet, a pure addition.
You can look at all the macro breakdowns in the paper. And the result was the Oreo cookies lowered my LDL by a dramatic 71%. And I'll just say as an aside.
You can look at all the macro breakdowns in the paper. And the result was the Oreo cookies lowered my LDL by a dramatic 71%. And I'll just say as an aside.
You can look at all the macro breakdowns in the paper. And the result was the Oreo cookies lowered my LDL by a dramatic 71%. And I'll just say as an aside.
Well, the fact of the matter is, I think you learn so much in science and medicine by studying the outliers. And when you do the randomized control trial, yes, it has certain benefits, but you're, by the nature of the study, looking at a large group of diverse humans. So when you get a, quote, statistically significant result, that doesn't speak to any individual in the trial.
Well, the fact of the matter is, I think you learn so much in science and medicine by studying the outliers. And when you do the randomized control trial, yes, it has certain benefits, but you're, by the nature of the study, looking at a large group of diverse humans. So when you get a, quote, statistically significant result, that doesn't speak to any individual in the trial.
Well, the fact of the matter is, I think you learn so much in science and medicine by studying the outliers. And when you do the randomized control trial, yes, it has certain benefits, but you're, by the nature of the study, looking at a large group of diverse humans. So when you get a, quote, statistically significant result, that doesn't speak to any individual in the trial.
And if we want to shift medicine towards more focusing on targeting underlying metabolic dysfunctions in an individual manner, then we need to start taking the mindset of N equals one medicine. And we have more and more tools where we can do this.
And if we want to shift medicine towards more focusing on targeting underlying metabolic dysfunctions in an individual manner, then we need to start taking the mindset of N equals one medicine. And we have more and more tools where we can do this.
And if we want to shift medicine towards more focusing on targeting underlying metabolic dysfunctions in an individual manner, then we need to start taking the mindset of N equals one medicine. And we have more and more tools where we can do this.
Things like multiomics, where we take an individual's genome and microbiome transcript and you integrate them into an incredibly high resolution picture of the individual. If you take that mindset, then you can get incredible results. in a reproducible manner, like lowering your LDL with Oreo cookies. I'm not saying that's healthy, I'm just saying it's incredible.
Things like multiomics, where we take an individual's genome and microbiome transcript and you integrate them into an incredibly high resolution picture of the individual. If you take that mindset, then you can get incredible results. in a reproducible manner, like lowering your LDL with Oreo cookies. I'm not saying that's healthy, I'm just saying it's incredible.
Things like multiomics, where we take an individual's genome and microbiome transcript and you integrate them into an incredibly high resolution picture of the individual. If you take that mindset, then you can get incredible results. in a reproducible manner, like lowering your LDL with Oreo cookies. I'm not saying that's healthy, I'm just saying it's incredible.
And it's explainable when you understand the physiology. And is it generalizable? I've actually had other doctors at Harvard replicate this who are lean mass hyper-responders. There are actually quite a decent number of lean mass hyper-responders, people at Keto at Harvard.
And it's explainable when you understand the physiology. And is it generalizable? I've actually had other doctors at Harvard replicate this who are lean mass hyper-responders. There are actually quite a decent number of lean mass hyper-responders, people at Keto at Harvard.
And it's explainable when you understand the physiology. And is it generalizable? I've actually had other doctors at Harvard replicate this who are lean mass hyper-responders. There are actually quite a decent number of lean mass hyper-responders, people at Keto at Harvard.