117: 5th WSC – The Research Agenda for AMR and Sepsis
episode
5th World Sepsis Congress: Sepsis Research and Innovations
1h 26m
2 chapters
transcribed 20 days ago
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What is the overall focus of Session 11 at the 5th World Sepsis Congress?
Thanks for continuing with us at the Fifth World Sepsis Congress. There's a session 11 titled The Research Agenda for AMR and Sepsis. You'll hear from six experts from all over the world addressing the global challenge of antimicrobial resistance in the context of sepsis. Louise Norton-Smith from CARPX is your moderator for today. Louise, take it away.
Good afternoon, uh good morning, good evening everybody, and thank you for joining us for this session number eleven of this year's World Sepsis Congress. And this session is focused on the research agenda for antimicrobial resistance and sepsis. And my name is Louise Norton Smith, and I am Director of External Affairs at CABEX, the combating antibiotic resistant bacteria accelerator. First of all, I would like to thank the organisers and the sponsors of this year's Congress, and I'm delighted to welcome our esteemed panel. We will hear from each of them in turn, leaving a few minutes, hopefully if we have enough time, at the end of each presentation for a brief question and answer session. So please do submit your question via the chat function.
So without further ado, I would like to introduce our first speaker, Dr. Benedict Huntner. And Benedict is the unit head of control and response strategies in the division of antimicrobial resistance at WHO headquarters in Geneva, leading their work on antimicrobial stewardship and antimicrobial use surveillance. Previously, Benedict was the team lead of Essential Medicines in the Division of Access to Medicine. Medicines and health products at WHO, where he led the development of the WHO Aware Antibiotic Book. Benedict obtained his medical degree in Munich, Germany, in 2001 and then moved to Switzerland to train in infectious diseases, where he subsequently worked as a clinician responsible for antimicrobial guidelines and stewardship at Geneva University Hospitals.
So Benedict will present WHO's global research priorities. for AMR and sepsis. Over to you, Benedict.
Thank you very much. Uh good afternoon from Geneva, everybody. I um don't have any uh conflicts of interest, but I'm a full time staff member of uh WHO. Quick outline of my presentation I want to first talk about the burden of antimicrobial resistance and a little bit about WHO's response, then address a global research research agenda for EMR focusing on sepsis and then um also mention some examples of You probably will see the similar slides several times. Antimicrobial resistance has a very important impact both on morbidity and mortality. You see that in that Lancet paper published last year, there are about 4.7 million deaths associated with AMR and 1.14 attributable to AMR. And are Large part of those deaths are obviously linked to sepsis.
And what is the difference between associated and attributable? It's just what is assumed as a counterfactual. Do you assume you can replace a resistance infection with no infection, or would it be replaced by infection as a susceptible organism? Depending on that, you get different results. Obviously, these results have to be interpreted with some caution because we We know that in the countries that have the highest burden, we also have the least comprehensive and representative data. And that's by the way, something WCO is working on, looking specifically at bloodstream infections, which is obviously not uh equivalent to sepsis, but with a significant overlap, to really try to get some uh representative data uh on uh what is the prevalence of AMR and how much how big is the burden.
in low middle income countries. So last year has been very important uh year for AMR. Why? Because there was a UN high-level meeting in New York and that uh is nearly 10 years after WHO first um member states first uh endorsed the global action plan on AMR. But um while we made some progress, there is still need for more progress at the country level. And um if you look at the um strategic and operational priorities, it's obviously a multi tongued approach with very important uh the prevention of infection.
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