121: 5th WSC – Prevention and Rehabilitation of Long-Term Sequelae From Sepsis

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5th World Sepsis Congress: Sepsis Research and Innovations 1h 45m 1 speaker 7 chapters transcribed 18 days ago
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What is the purpose of Session 15 on sepsis survivorship?

Unknown 0:01
Hello there! This is session 15, the final session of the Fifth World Sepsis Congress. Prevention and rehabilitation of long-term sequelae from sepsis. Today's speakers explore how to support survivors on the path to recovery and long-term well-being, a topic still very much neglected. Nathan Nielsen from the US will be our moderator today. Nathan, over to you. Let's finish strong.
Nathan Nielsen 0:30
Hello everyone, welcome back and welcome to the final session of the twenty twenty-five World Sepsis Congress. We are going to end on a high note, I swear. No, truly. We have an exceptional group of speakers to close out this Congress with. And we're going to address something that I think is absolutely essential. We're going to talk about survivorship. And how survivors deal with recovering from sepsis. You know, as a sepsis clinical trialist myself, we get very excited when we say, Hey, they survived. But we forget that that's not the end. Right. Surviving is just the beginning of the patient's journey with sepsis and it can linger years and years into the future. So a a I think to date grossly under studied and underappreciated element of the sepsis path uh pathway and the sepsis journey.
Nathan Nielsen 1:23
But I think one that our speakers here are really working hard to try and rectify and trying to add to our knowledge and our understanding of this these effects in the long term. Oh god, introductions. Myself, I'm Dr. Nathan Nielsen. I'm an intensivist and blood banker at the University of New Mexico. a longtime sepsis clinical trialist and um a proud member and supporter of the GSA for uh more years than I care to admit right now. So uh without further ado, I'm gonna get out of the way and let the experts do the talking. And our journey begins in South America down in Buenos Aires. Dr. Ivan Alfredo Westpe. I hope I got that close to correct. Just for introduction, Dr. Westpe is a critical care physician and the head of critical care research.
Nathan Nielsen 2:09
at the Hospital Italiano de Buenos Aires, and their specialization is developing causal and predictive models for mortality as complications in critical care patients, particularly with a focus on sepsis. And he is going to be speaking to us all about how, or I should say, on predicting long term cardiovascular complications following sepsis, an important sequela. So without further ado, doctor Westbe, the microphone is yours.
Iván Alfredo Huespe 2:38
Well, thanks a lot, Nathan, for the introduction. I'm the head of the research section up here in the Hospital Italiano de Buenos Aires, the section in research and critical care, but also I am an external researcher from the Mayo Clinic in Jacksonville, Florida. And today we are going to talk how we are working in the production of length long-term complications, especially cardiovascular complications. After sepsis is charged. And as we know, sepsis remains a significant global health problem. However, due to the medical treatment and improvement, the survival after sepsis is increasing. Therefore, right now, we are having a rising population of post-sepsis survival. These patients, the 70% of them, will have physical, medical, and cognitive, and physiological complications.
Iván Alfredo Huespe 3:28
after sepsis discharge, but today especially about the cardiovascular complication. After sepsis discharge, patients will have an increasing risk of acute hair failure, myocardial infraction, and any kind of stroke. In fact, we know from science 2024 that patients discharge for pneumonia, for example, Have an increased cardiovascular risk that persists even 10 years after discharge. And it was published in 2021 a really interesting meta-analysis that found that patients discharged from sepsis have long-term cardiovascular complications equal to patients who have hypertension, dyslipemia, or diabetes. Even so, several sepsis survivors. have a twofold increase in cardiovascular risk, and that's important even between patients who don't have cardiovascular comorbidities previous to the hospitalization due to sepsis.
Iván Alfredo Huespe 4:24
Well, the causes of this increased risk are right now not so clear.

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