119: 5th WSC – State of the Art in Sepsis Research: Emerging Immunomodulatory Approaches
episode
5th World Sepsis Congress: Sepsis Research and Innovations
1h 27m
8 chapters
transcribed 25 days ago
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What is the overall focus of the session and who are the moderators?
You're now with us for session 13 of the 5th World Sepsis Congress. This one is titled State of the Art and Sepsis Research: Emerging Immunomoderatory Approaches. In this session, experts explore new ways to target the immune response in sepsis. Imran Amalik leads today's discussion. Let's begin.
Good morning, good afternoon, or good evening, depending on your time zone. I am excited to welcome our global audience to session number 13 titled State of the Art in Sepsis Research: Emerging Immunomodulatory Approaches. This is an extremely interesting topic at the very forefront of sepsis care. My name is Imran Amulik and I will be your moderator for this session. I'm an intensivist at MD Anderson Cancer Center in Houston, Texas, in the United States, with an interest in sepsis and cancer patients. I am also a member of the executive committee of the Global Substance Alliance. Before we begin, a quick thank you to our Congress sponsors, Sonofi, BioMaru, ThermoFisher, Adrenomed, and 144. Now for some housekeeping items, uh, we have some excellent uh six speakers today, and we hope to have time for approximately one to two questions after each talk.
Please make sure to add the letter Q before your question to differentiate it from the general comments in the chat. Please also note that our third talk of today, uh today's session by Dr. Nawala Meyer is prerecorded, so she will not be present to take any questions. Now it is my distinct privilege to introduce our first speaker, Doctor Evangelos Giamarellos Borbolis. Dr. Gia Morelis Barbolas is a professor of internal medicine and infectious disease at the Medical School of the National and Capodistrian University of Athens since 2018. He was trained in the immunology of infections at the Department of Internal Medicine and Infectious Disease at Rodwood University in the Netherlands. In two thousand twelve and twenty thirteen, he served as a guest professor of the Department of Critical Care Medicine at Jena University Hospital in Germany.
His main research contribution is immunomodulation in sepsis and in auto inflammatory disorders, for which he was awarded the Young Investigator Research Award by the European Society of Clinical Microbiology and Infectious Diseases. He has over four hundred publications intern in international peer reviewed journals. with more than twenty seven thousand citations and in a very impressive H index of eighty. He is the current chair of the European Sepsis Alliance, and his main achievement is the approval of Anachinra for COVID-19 pneumonia in adults by the European Medicines Agency and the Food and Drug Administ Administration through the phase two and three trials of Save and Save More that he designed and conducted.
His presentation today is titled Immunomodulatory therapies, where are we currently? Welcome, Dr. Gia Morellus For Wolis.
Well, thank you very much for your kind words and it's really a privilege and an honor to be uh this late afternoon for me. Uh, according to my time zone, to discuss about immunomodulative therapies and where we are currently are. Uh beforehand, I would like to say that I will not speak about the topics of my of the other uh distinguished speakers of this session. And uh today, as uh you see, I'm representing the European Sepsis Alliance. This is my conflict of interdisclosure for this talk. And actually, this what we are speaking about precision immunotherapy nowadays. This is a situation which all of us have experienced during COVID-19. Imagine that we're doing our regular consultation in the ward. And the first patient who's intubated and we come across is a patient who, although of course he's ERD he has ERDS, of course he's intubated, of course he's under resuppressors, like all other patients.
But his characteristics is that He has an extremely high CRP and extremely high ferritin. The patient who lies next to him is at a similar clinical state, yet the concentration of CRP is not that increased to such a level that the fellows are really impressed. And the third patient
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Chapters
8 chapters
1
What is the overall focus of the session and who are the moderators?
0:02–9:41
2
How does Dr. Evangelos Giamarellos‑Bourboulis describe the current state of immunomodulatory therapies for sepsis?
9:41–18:56
3
What are the key findings from the TREM‑1 inhibition trial presented by Dr. Bruno François?
18:56–30:42
4
How does Dr. Nuala Meyer explain the role of IL‑6 inhibition in sepsis and COVID‑19?
30:42–44:16
5
What precision‑medicine strategies are being tested in pediatric sepsis by Dr. Mark Hall?
44:16–54:13
6
How does Dr. Stephan Witt propose targeting the vascular endothelium with adrenomedulin?
54:13–1:03:47
7
What is the rationale and early data for C5a inhibition in sepsis presented by Dr. Michael Bauer?
1:03:47–1:14:26
8
What are the next steps and take‑away messages for emerging immunomodulatory approaches in sepsis?
1:14:26–1:27:00
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