120: 5th WSC – Sepsis in Emergencies and Humanitarian Crisis
episode
5th World Sepsis Congress: Sepsis Research and Innovations
1h 21m
8 chapters
transcribed 24 days ago
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What is the focus of Session 14 and who is moderating the discussion?
Welcome back to the 5th World Sepsis Congress. This is session 14, Sepsis in Emergencies and Humanitarian Crisis. Our speakers today share insights from the front lines in areas affected by conflict, disaster, and displacement. Settings in which sepsis is even worse than in normal settings. Antonio Artigas from Spain is your moderator for this timely conversation. Antonio, the stage is yours.
Hello, антоніортигам Spain and member of the uh board committee of the global service alliance and the chairman of the uh translational uh lab in my hospital and it's a pleasure uh an honor uh to share this session on sepsis in emergencies and humanitarian. I I think this will be a very exciting uh session. I hope that you will not be too tired uh after this long day of uh presentations. And I would like to to thank all the sponsors uh to make this uh possible. So I would like to uh to introduce the first speaker. The first speaker is uh Janet Diaz.
How does Janet Diaz define the objectives for managing filovirus‑related sepsis during outbreaks?
Uh Janet he will present the Philovirus and sepsis optimizing management during outbreaks. Janet is a specialist in intensive care and pulmai medicine and is she's uh an expertise in clinical medicine and medical education and quality improvement. He is ha he has been uh working in WHO as a lead uh for clinical management and operation unit in the health emergency programme. So uh Jeanette, the floor is for you.
Thank you so much, Antonio, for the introduction and good morning, good afternoon, good evening, colleagues.
What are the key clinical and immunological features of filovirus‑associated sepsis?
Uh really nice to be here and thanks to the Global Sepsis Alliance uh for conducting this um sepsis congress. Uh and it's my pleasure to be here. I'm gonna keep moving here. So what are the objectives of this talk? Uh first I want to describe why phylovirus outbreaks are a public health emergency, describe what are the clinical and immunological characteristics of phylovirus associated sepsis, and then how do we best manage phylovirus outbreaks using a holistic and integrated approach to reduce mortality? So the virus itself, for those of you that are uh not familiar with it or or haven't thought about it in a while, um, this is the phylovirus family. It has two big buckets of genus, I guess, or subfamilies, the Ebola viruses, which many of you may be familiar with.
That was the cause of the big West African outbreak in 2014, and that includes Ayer virus. And then also recently we've been having more outbreaks of the Sudan uh Ebola virus. And then the other bucket is Marburg viruses, which also we've had recently had uh multiple outbreaks over the past few years.
Which major filovirus outbreaks have shaped current treatment guidelines and what were their case‑fatality rates?
This is a complex slide, but I think it was one that I wanted to show because it's showing On the x-axis, uh a timeline. So really since the uh emerge since the detection of phylovirus in humans, uh how many outbreaks we've had, and there you see Marburg detected in nineteen sixty-seven, all the way up to the present time where currently uh we are um having an outbreak of Sudan virus in Uganda. And there you see on the Y-axis the case fatality ratios. And these vary between outbreaks and you can see some low, some very, very high, a lot that are actually very, very high above 90 or 100%. Over the years. I did want to highlight the two thousand fourteen um uh West African outbreak, uh two thousand thirteen West African outbreak, and highlight there where the commun where the average uh CFR was around forty percent.
So that was the largest one, and I think it affected over twenty eight thousand people in West Africa. The next one I wanted to highlight is the next second largest outbreak uh that occurred from Ebola Zaire virus, which was in the D Democratic Republic of Congo. And that outbreak had uh affected around two thousand five hundred individuals in uh and resulting in a CFR of around forty two percent. And the reason I wanted to highlight that was because that's actually where A a very high quality clinical trial was conducted, the POM trial, which gave us um actually high quality evidence uh for some effective uh anti uh monoclonal antibodies against a Urovirus, which I'm gonna describe later.
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Chapters
8 chapters
1
What is the focus of Session 14 and who is moderating the discussion?
0:02–1:19
2
How does Janet Diaz define the objectives for managing filovirus‑related sepsis during outbreaks?
1:19–1:59
3
What are the key clinical and immunological features of filovirus‑associated sepsis?
1:59–2:57
4
Which major filovirus outbreaks have shaped current treatment guidelines and what were their case‑fatality rates?
2:57–26:56
5
How has the war in Sudan impacted sepsis care, infrastructure, and patient outcomes?
26:56–42:52
6
What practical solutions (mobile clinics, tele‑medicine, community networks) are being used to restore sepsis services in war‑torn Sudan?
42:52–1:05:55
7
How does climate change influence maternal, newborn and child sepsis, and what evidence supports this link?
1:05:55–1:20:24
8
What are the recommended actions for donors, policymakers, and humanitarian agencies to ensure resilient sepsis care during emergencies?
1:20:24–1:21:28
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