The a16z Show

On Fear and Leadership: Product to Sales CTOs & CEOs

04 Dec 2020

Contributed by Lukas

There's a few ontologies for describing the phases leaders -- and their startups -- go through, whether it's product-sales-etc. or pioneer to settler....

On Food As Medicine (A Holiday Snack)

26 Nov 2020

Contributed by Lukas

What happens if we treat food as a medicine in the healthcare system: How, where, and who (pays)? What role can technology play in increasing access, ...

Crypto Creators: On Art Galleries to 'Tokenized' Collectibles

22 Nov 2020

Contributed by Lukas

This episode features Q&As with two artists who are exploring crypto-powered auction sites and marketplaces – this is part of our ongoing series on ...

What to Know about Those Vaccines

20 Nov 2020

Contributed by Lukas

A vaccine for COVID seems to be (almost) here… or is it? What’s hype/ what’s real beyond the headlines (and beyond the press release), when it c...

The Social Serendipity of Cloud Gaming

16 Nov 2020

Contributed by Lukas

True cloud-native games—those exclusive to and solely playable within the cloud—are poised to revolutionize gameplay and unlock new avenues of hyp...

The Great Data Debate

13 Nov 2020

Contributed by Lukas

Lakes v. warehouses, analytics v. AI/ML, SQL v. everything else... As the technical capabilities of data lakes and data warehouses converge, are the s...

How to Moderate Talks, Panels, Meetings, More (Virtual and Beyond!)

05 Nov 2020

Contributed by Lukas

How to moderate good, productive discussions and navigate tricky conversations is top of mind -- whether doing a panel, conducting a live event, prese...

Textiles as Tech, Science, Math, Culture... or Civilization

24 Oct 2020

Contributed by Lukas

"The most profound technologies are those that disappear. They weave themselves into the fabric of everyday life until they're indistinguishable from ...

Data Alone Is Not Enough: The Evolution of Data Architectures

23 Oct 2020

Contributed by Lukas

Data, data, data – it’s long been a buzzword in the industry, whether big data, streaming data, data analytics, data science, even AI & machine le...

Designing for, Marketing to, and Partnering With Gen Z

19 Oct 2020

Contributed by Lukas

Gen Z—those born between 1995 and 2010—now makes up 35 percent of the population and represent $143 billion dollars in spending power. This episod...

The Present Future of Audio: Talk, Music, Video, Interactivity

14 Oct 2020

Contributed by Lukas

We've already talked a lot about podcasting, both evolution of the industry as well as the form, but where are we going with the future of audio, more...

Tracking the Trends: AI, WebRTC, Crypto, and Full Stack Startups

11 Oct 2020

Contributed by Lukas

Stay Updated:Find a16z on XFind a16z on LinkedInListen to the a16z Podcast on SpotifyListen to the a16z Podcast on Apple PodcastsFollow our host: http...

How to Decide, Convey vs. Convince, & More

08 Oct 2020

Contributed by Lukas

It seems like investors are especially obsessed with the psychology of decision making -- high stakes, after all -- but all kinds of decisions, whethe...

Fintech for Gen Z and Millennials

01 Oct 2020

Contributed by Lukas

Millennials and Gen Z have been hard-hit by the one-two punch of the 2008 and 2020 financial crises. That experience has radically shaped their approa...

Degrading Drugs for Problem Proteins: Journal Club now on Bio Eats World (ep 2)

27 Sep 2020

Contributed by Lukas

Welcome to the second episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic an...

The Biology of Aging: Introducing Bio Eats World (ep 1)

23 Sep 2020

Contributed by Lukas

Welcome to the first episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and...

TikTok & Beyond: The Algorithm Question, The Future of Product

20 Sep 2020

Contributed by Lukas

With the U.S. tech partnership for TikTok being finalized, what happens if source code is excluded (and more specifically, the For You Page algorithm)...

The New Fan Club: Creators, Fans, and the Power of Markets (& Crypto)

18 Sep 2020

Contributed by Lukas

Today’s episode, part two in our two-part series on the Creator Economy, focuses on the new potential revenue streams and fan-engagement models open...

So You Want to Launch a Newsletter: Tips From Substack Writers

17 Sep 2020

Contributed by Lukas

This episode, part one in a two-part series on the Creator Economy, explores the process and economics behind creating an independent newsletter. In t...

Designing a Culture of Reinvention

15 Sep 2020

Contributed by Lukas

Since Netflix started in the late 90s as a DVD-by-mail rental service competing with Blockbuster, it has completely reinvented itself... twice – fir...

Heroes & Myths in Entrepreneurship -- Guy Raz

12 Sep 2020

Contributed by Lukas

"I'm in a movie, but it's the wrong movie."For better or for worse, we tell the story of entrepreneurs as one of the mythical hero's journey: that's t...

The Question of Education

11 Sep 2020

Contributed by Lukas

Monopoly, oligopoly, cartel. All three of those words can describe the (not so) modern education system today, given the cost structures, economics, a...

Pandemic Relief and Fraud: Willful Deceit or Design Defect?

04 Sep 2020

Contributed by Lukas

This episode examines the potential for misuse and fraud among those applying for the Paycheck Protection Program (PPP)—and how fintech and software...

Measuring & Managing Community Orgs, Developer Relations and Beyond

30 Aug 2020

Contributed by Lukas

Okay, so we know community is important -- whether for developer relations for your product or other types of communities -- but how do we measure the...

Reining in Complexity: Data Science & Future of AI/ML Businesses

21 Aug 2020

Contributed by Lukas

There is no spoon. Or rather, “There is no such thing as ‘data’, there’s just frozen models”, argues Peter Wang, the co-founder and CEO of A...

Online Learning and the Ed Tech Debate

17 Aug 2020

Contributed by Lukas

This episode is all about education and technology, a topic that’s especially top of mind this week as students in much of the country return to sch...

On Vaccines and Vaccinology, in COVID and Beyond

14 Aug 2020

Contributed by Lukas

WHEN are we going to have a COVID-19 vaccine, and how the heck are we going from (what’s been traditionally been up to) 12 years or so of vaccine de...

Turning Open Source Developers Into Superfans

10 Aug 2020

Contributed by Lukas

In this episode, we continue our community series with a recent discussion that applies to many kinds of community building. Today’s topic: How do y...

Journal Club: Slaying the Sleeper Cells of Aging with CAR T

09 Aug 2020

Contributed by Lukas

CAR T therapy is a groundbreaking medicine that uses engineered T cells to attack cancer. But CAR T cells (that is, chimeric antigen receptor T cells)...

Working, Making, Creating in Public... and Private

02 Aug 2020

Contributed by Lukas

We're living in an unprecedented era of online collaboration, coordination, and creation. All kinds of people are coming together -- whether in an ope...

GPT-3: What's Hype, What's Real on the Latest in AI

30 Jul 2020

Contributed by Lukas

In this episode -- cross posted from our 16 Minutes show feed -- we cover all the buzz around GPT-3, the pre-trained machine learning model from OpenA...

Taking the Pulse on Medical Device Security

22 Jul 2020

Contributed by Lukas

Many don’t realize we even need to think about the possibility of security hacks when it comes to things like pacemakers, insulin pumps, and more. B...

Journal Club: A New Path to Antibiotic Resistance

19 Jul 2020

Contributed by Lukas

Ever since the discovery of antibiotics, microbiologists have worried about and studied how bacteria acquire resistance to these drugs. Adding to the ...

Cybercrime, Incorporated

18 Jul 2020

Contributed by Lukas

A dive into the sociological, operational, and tactical realities of this murky underworld, Lusthaus and de la Garza discuss who the players are, what...

How Transparent Pricing Drives Healthcare Change

15 Jul 2020

Contributed by Lukas

Dr. Marty Makary—surgical oncologist at Johns Hopkins University School of Medicine, and health policy and innovation expert—has long been a passi...

Preserving Digital History: How to Close the Web's 'Memory Hole'

13 Jul 2020

Contributed by Lukas

More than 98% of the information on the web is lost within 20 years, and huge gaps exist in our digital and cultural history. Zoran Basich and Alex Pr...

Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship

11 Jul 2020

Contributed by Lukas

In part 1 of our series on human performance, we looked at the limits of human potential in climbing and other sports – and how we push those limits...

Alex Honnold on Human Performance (part 1) – Where's the Limit?

11 Jul 2020

Contributed by Lukas

Is there a limit to what humans can do? And if so, how do you know when you've reached it? Welcome to part one of a two-part series on human performan...

Why We Shouldn’t Fear AI in Healthcare

07 Jul 2020

Contributed by Lukas

"Why We Shouldn’t Fear the ‘Black Box’ of AI (in Healthcare and Everywhere)" by Vijay Pande. First published in the New York Times, January 2018...

When One App Rules Them All: The Case of WeChat and Mobile in China

07 Jul 2020

Contributed by Lukas

"When One App Rules Them All: The Case of WeChat and Mobile in China" by Connie Chan. First published August 2015. You can also find and share this e...

Every Company Is a Fintech Company

07 Jul 2020

Contributed by Lukas

"Why Every Company Will Be a Fintech Company -- The Next Era of Financial Services and the 'AWS Phase' for Fintech" by Angela Strange.You can also fin...

Read-Alouds, Continued

07 Jul 2020

Contributed by Lukas

Today we're continuing a series we started a while ago of read-alouds (for more context on the why and why now check out episode #500 on how we podcas...

Journal Club: Revisiting Eroom's Law

05 Jul 2020

Contributed by Lukas

Eroom’s Law is Moore’s Law spelled backwards. It’s a term that was coined in a Nature Reviews Drug Discovery article by researchers at Sanford B...

Preventing Pandemics with Genomic Epidemiology

30 Jun 2020

Contributed by Lukas

The COVID-19 pandemic has increased the visibility of scientists and the scientific process to the broader public; suddenly, scientists working on vir...

Journal Club: Therapeutic Video Game on Trial

28 Jun 2020

Contributed by Lukas

In this episode of the a16z bio journal club, we cover one of the key clinical trials that supported the recent FDA approval of the first prescription...

Gross Margins, Early to Late: What They Do (and Don't) Tell You

27 Jun 2020

Contributed by Lukas

Gross margins are essentially a company's revenue from products and services minus the costs to deliver those products and services to customers, and ...

Building Products for Power Users

24 Jun 2020

Contributed by Lukas

As more digital natives have entered the workplace, they have brought with them the expectation that their software should both be a joy to use and al...

Journal Club: Building a Better Chloroplast

21 Jun 2020

Contributed by Lukas

In this episode of the a16z bio Journal Club, bio deal team partner Judy Savitskaya and Lauren Richardson discuss research that aims to enhance the ef...

Real Estate in a Pandemic: Renters and Landlords (Part 2)

17 Jun 2020

Contributed by Lukas

This episode is the second in a two-part series that examines the pandemic’s impact on real estate. Part 1 focused on prospective home buyers, selle...

Real Estate in a Pandemic: Homeowners and Buyers (Part 1)

16 Jun 2020

Contributed by Lukas

This episode is the first in a two-part series that examines the pandemic’s impact on real estate. Part 1 focuses on prospective home buyers, seller...

World’s Largest Supercomputer v. Biology’s Toughest Problems

14 Jun 2020

Contributed by Lukas

Proteins are molecular machines that must first assemble themselves to function. But how does a protein, which is produced as a linear string of amino...

The Return of Home-based Healthcare

12 Jun 2020

Contributed by Lukas

The way we deliver healthcare has changed enormously over the last century, shifting from house calls by doctors to your own to institutionalized sett...

The Future of Primary Care

11 Jun 2020

Contributed by Lukas

Primary care was meant to be the front door to the healthcare system, but in some ways never set up for success to begin with. We need a new operating...

All about Section 230: What It Does and Doesn't Say

09 Jun 2020

Contributed by Lukas

 We cover the tricky but important topic of Section 230 of the Communications Decency Act. The 1996 law has been in the headlines a lot recently, in ...

What We Can't Reveal We Can't Heal

04 Jun 2020

Contributed by Lukas

Given recent events around George Floyd and far beyond, this special episode of the a16z Podcast features Shaka Senghor, a leading advocate for crimi...

SaaS Go-to-Upmarket

29 May 2020

Contributed by Lukas

For a SaaS company, it's easier to move upmarket than down, and this gives SaaS startups the advantage against incumbents. In this episode,  David Ul...

New Fan Engagement Models for Athletes and Influencers

26 May 2020

Contributed by Lukas

Today’s episode is about a practical application of crypto — namely, the way it can “tokenize” fandom. More broadly, it’s about fan engageme...

Don't Call it a Brain in a Dish!

24 May 2020

Contributed by Lukas

Our understanding of the human brain and its disorders has always been limited by our lack of access to living, human, developing brain tissue. For th...

Pandemics: Early Detection, Networks, Spreaders

23 May 2020

Contributed by Lukas

Pandemics are predictable; what's not predictable is the intensity, or the precise timing of arrival. That's where early detection -- not just rapid w...

Podcasting and the Future of Audio

20 May 2020

Contributed by Lukas

This podcast (first recorded in 2019, now being rerun) -- is a podcast about podcasting: But it's really all about audio. A lot's changed... and a lot...

Growth in Turbulent Times

15 May 2020

Contributed by Lukas

 In normal times, every company operates against some hypothetical growth model—a data-driven framework that describes how your product grows and h...

Journal Club: Using CRISPR to Prevent Coronavirus and Influenza Infection

15 May 2020

Contributed by Lukas

In this episode of a16z bio Journal Club, general partner Vijay Pande, bio deal team partner Andy Tran, and bio editor Lauren Richardson discuss a nov...

What's Next in Gaming

07 May 2020

Contributed by Lukas

Video game technology has evolved into a global phenomenon that extends far beyond entertainment. In this episode, John Riccitiello, CEO of the game s...

Undruggable Drugs

06 May 2020

Contributed by Lukas

In this episode of the a16z Podcast, we take a deep dive into the world of drug development—specifically "undruggable drugs": a category of protein,...

The Next Generation of Cultural Influencers in Tech

02 May 2020

Contributed by Lukas

This episode—which originally took place as a live event—is a conversation between Seattle Seahawks linebacker Bobby Wagner and a16z Cultural Lead...

The Chief Security Officer in (and out of) a Crisis

29 Apr 2020

Contributed by Lukas

The Chief Security Officer (CSO/CISO) used to manage on-premise servers, now the information they have to secure has migrated to the cloud. As the res...

Journal Club: Finding New Antibiotics with Machine Learning, What Coronavirus Structures Tell Us

26 Apr 2020

Contributed by Lukas

a16z Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and wh...

Introducing Journal Club

26 Apr 2020

Contributed by Lukas

Announcing a16z Journal Club, a new show where we curate and discuss recent research papers with a16z experts and others. This new show continues the...

What the Narrow Waist of the Internet Means for Innovation Today

24 Apr 2020

Contributed by Lukas

Here is Ali's tweetstorm on the Narrow Waist of Blockchain Computing  Stay Updated:Find a16z on XFind a16z on LinkedInListen to the a16z Podcast on S...

IT'S TIME TO BUILD

21 Apr 2020

Contributed by Lukas

“It's Time to Build” by Marc Andreessen. You can also find and share this essay at a16z.com/build Stay Updated:Find a16z on XFind a16z on LinkedI...

Introducing Read Alouds

21 Apr 2020

Contributed by Lukas

We wanted to let you know about a special new series of posts occasionally read out loud from us  (you can learn more about the why and why now in ep...

The Passion Economy: Redefining Work

18 Apr 2020

Contributed by Lukas

This episode of the a16z Podcast covers the the rise of online platforms that enable people to make a living off their unique interests and skills. It...

When Bad Policy = Bad Business Models = Bad Public Health

16 Apr 2020

Contributed by Lukas

with @JorgeCondeBio, @julesyoo, and @omnivorousreadIn some ways, the coronavirus feels like it came out of nowhere—a kind of Black Swan event. But a...

Moving to Remote Development (and Work)

15 Apr 2020

Contributed by Lukas

From agile project management to asynchronous collaboration, development teams have pioneered many of the tools and best practices for remote work. Ho...

Virtual Oncology

10 Apr 2020

Contributed by Lukas

with @vintweeta @pbcancerdoc @sumitshahmd @omnivorousreadCoronavirus is now disrupting the entire health care system, not just because of the burden o...

The Story of Schizophrenia

07 Apr 2020

Contributed by Lukas

Descriptions of the mental illness we today call schizophrenia are as old as humankind itself. And more than likely, we are are all familiar with this...

Navigating the Numbers

04 Apr 2020

Contributed by Lukas

For any business, there are three core financial statements – the income or P&L statement, the balance sheet, and the cash flow statement. While the...

Gaming and Livestreaming: Connecting While Distancing

02 Apr 2020

Contributed by Lukas

Since social distancing measures were first put in place, time spent gaming has gone up—way up. According to a recent report by Verizon, video game ...

The Hustlers's Guide to Suing the Man

01 Apr 2020

Contributed by Lukas

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for p...

The Hustler's Guide to Elder Care

01 Apr 2020

Contributed by Lukas

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for p...

The Hustler's Guide to Nursing Jobs

30 Mar 2020

Contributed by Lukas

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for p...

Hustlin' Tech, Round Two

30 Mar 2020

Contributed by Lukas

This is the next cycle of Hustlin' Tech -- a podcast series co-hosted by bestselling authors, a16z co-founder Ben Horowitz; and Shaka Senghor, a leadi...

Security When the Workforce Goes Remote

27 Mar 2020

Contributed by Lukas

We are in the midst of a rapid and unprecedented shift to remote work. What does it mean for security when the airgap between work and life is gone? H...

The Delivery-Optimized Future of Food

25 Mar 2020

Contributed by Lukas

The spike in online ordering and food delivery—a trend that's particularly relevant now—is evidence of how tech is fundamentally changing how and ...

Remote Work and Our New Reality

23 Mar 2020

Contributed by Lukas

Stay Updated:Find a16z on XFind a16z on LinkedInListen to the a16z Podcast on SpotifyListen to the a16z Podcast on Apple PodcastsFollow our host: http...

When Medicine Goes Virtual

19 Mar 2020

Contributed by Lukas

We’re at a moment where we are now seeing medicine go virtual faster, and at a scale that it has never done before. In this conversation,  a16z ...

Labs for Diagnostics: Then, Now, and Next

17 Mar 2020

Contributed by Lukas

A lot's going on in the world of healthcare right now, and one topic that's especially relevant is how diagnostic labs work. In this episode with Dave...

How a16z's Crypto Startup School Went Remote

14 Mar 2020

Contributed by Lukas

On February 21, Andreessen Horowitz kicked off its very first Crypto Startup School, with 45 students from around the U.S. and three countries gatheri...

When Fintech Meets Social

12 Mar 2020

Contributed by Lukas

The last financial crisis prompted many consumers to reassess their banking expectations—none more so than millennials and Gen-Z-ers. While revealin...

Innovation Through Software Development and IT

06 Mar 2020

Contributed by Lukas

One of the recurring themes we talk about a lot on the a16z Podcast is how software changes organizations, and vice versa... More broadly: it’s real...

The Open Source CIO

28 Feb 2020

Contributed by Lukas

In 2014, in "Why There Will Never Be Another Red Hat," Peter Levine argued that Red Hat’s open source business model of commercializing support and ...

Novel Coronavirus Updates: How Healthcare System, Tests Work; More

27 Feb 2020

Contributed by Lukas

This episode covers the following -- since our previous deep-dive on the novel coronavirus outbreak -- including:practical implications for the U.S. h...

Metrics and Mindsets for Retention & Engagement

20 Feb 2020

Contributed by Lukas

It's "Marketplaces Week" for us at a16z, thanks to our consumer team releasing a new index of the next industry-defining marketplaces, the Marketplace...

Tough Love, Global Diplomacy, and Lessons on Leadership

14 Feb 2020

Contributed by Lukas

Susan shares how she learned to leverage the characteristics of her personality early in her career as assistant secretary of state [2:05]One of the i...

Building the First CAR T Company

07 Feb 2020

Contributed by Lukas

with @OzAzamTmunity1, @JorgeCondeBio, and @omnivorousreadCAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer...

Rebel Talent

04 Feb 2020

Contributed by Lukas

When we think about rebellious behavior in the context of organizations and companies, we tend to think of rebels as trouble-makers, rabble-rousers; i...

All about the Coronavirus

30 Jan 2020

Contributed by Lukas

This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV...

The Truth about 1000 True Fans + Pricing Our Attention

27 Jan 2020

Contributed by Lukas

The idea of "1000 true fans" -- first proposed by Kevin Kelly in 2008 and later updated for Tools of Titans -- argued that to be a successful creator,...

Writers Writing, Readers Reading, Creators Creating

27 Jan 2020

Contributed by Lukas

We've been financing good writing with bad advertising -- and "attention monsters" (to quote Craig Mod) for way too long. So what happens when the tec...

What's Next for the Internet?

19 Jan 2020

Contributed by Lukas

How can we evolve the web for a better future? Has the web become a mature platform — or are we still in the early days of knowing what it can do an...