The a16z Show

Journal Club: A New Path to Antibiotic Resistance

19 Jul 2020

Contributed by Lukas

Ever since the discovery of antibiotics, microbiologists have worried about and studied how bacteria acquire resistance to these drugs. Adding to the ...

Cybercrime, Incorporated

18 Jul 2020

Contributed by Lukas

A dive into the sociological, operational, and tactical realities of this murky underworld, Lusthaus and de la Garza discuss who the players are, what...

How Transparent Pricing Drives Healthcare Change

15 Jul 2020

Contributed by Lukas

Dr. Marty Makary—surgical oncologist at Johns Hopkins University School of Medicine, and health policy and innovation expert—has long been a passi...

Preserving Digital History: How to Close the Web's 'Memory Hole'

13 Jul 2020

Contributed by Lukas

More than 98% of the information on the web is lost within 20 years, and huge gaps exist in our digital and cultural history. Zoran Basich and Alex Pr...

Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship

11 Jul 2020

Contributed by Lukas

In part 1 of our series on human performance, we looked at the limits of human potential in climbing and other sports – and how we push those limits...

Alex Honnold on Human Performance (part 1) – Where's the Limit?

11 Jul 2020

Contributed by Lukas

Is there a limit to what humans can do? And if so, how do you know when you've reached it? Welcome to part one of a two-part series on human performan...

Why We Shouldn’t Fear AI in Healthcare

07 Jul 2020

Contributed by Lukas

"Why We Shouldn’t Fear the ‘Black Box’ of AI (in Healthcare and Everywhere)" by Vijay Pande. First published in the New York Times, January 2018...

When One App Rules Them All: The Case of WeChat and Mobile in China

07 Jul 2020

Contributed by Lukas

"When One App Rules Them All: The Case of WeChat and Mobile in China" by Connie Chan. First published August 2015. You can also find and share this e...

Every Company Is a Fintech Company

07 Jul 2020

Contributed by Lukas

"Why Every Company Will Be a Fintech Company -- The Next Era of Financial Services and the 'AWS Phase' for Fintech" by Angela Strange.You can also fin...

Read-Alouds, Continued

07 Jul 2020

Contributed by Lukas

Today we're continuing a series we started a while ago of read-alouds (for more context on the why and why now check out episode #500 on how we podcas...

Journal Club: Revisiting Eroom's Law

05 Jul 2020

Contributed by Lukas

Eroom’s Law is Moore’s Law spelled backwards. It’s a term that was coined in a Nature Reviews Drug Discovery article by researchers at Sanford B...

Preventing Pandemics with Genomic Epidemiology

30 Jun 2020

Contributed by Lukas

The COVID-19 pandemic has increased the visibility of scientists and the scientific process to the broader public; suddenly, scientists working on vir...

Journal Club: Therapeutic Video Game on Trial

28 Jun 2020

Contributed by Lukas

In this episode of the a16z bio journal club, we cover one of the key clinical trials that supported the recent FDA approval of the first prescription...

Gross Margins, Early to Late: What They Do (and Don't) Tell You

27 Jun 2020

Contributed by Lukas

Gross margins are essentially a company's revenue from products and services minus the costs to deliver those products and services to customers, and ...

Building Products for Power Users

24 Jun 2020

Contributed by Lukas

As more digital natives have entered the workplace, they have brought with them the expectation that their software should both be a joy to use and al...

Journal Club: Building a Better Chloroplast

21 Jun 2020

Contributed by Lukas

In this episode of the a16z bio Journal Club, bio deal team partner Judy Savitskaya and Lauren Richardson discuss research that aims to enhance the ef...

Real Estate in a Pandemic: Renters and Landlords (Part 2)

17 Jun 2020

Contributed by Lukas

This episode is the second in a two-part series that examines the pandemic’s impact on real estate. Part 1 focused on prospective home buyers, selle...

Real Estate in a Pandemic: Homeowners and Buyers (Part 1)

16 Jun 2020

Contributed by Lukas

This episode is the first in a two-part series that examines the pandemic’s impact on real estate. Part 1 focuses on prospective home buyers, seller...

World’s Largest Supercomputer v. Biology’s Toughest Problems

14 Jun 2020

Contributed by Lukas

Proteins are molecular machines that must first assemble themselves to function. But how does a protein, which is produced as a linear string of amino...

The Return of Home-based Healthcare

12 Jun 2020

Contributed by Lukas

The way we deliver healthcare has changed enormously over the last century, shifting from house calls by doctors to your own to institutionalized sett...

The Future of Primary Care

11 Jun 2020

Contributed by Lukas

Primary care was meant to be the front door to the healthcare system, but in some ways never set up for success to begin with. We need a new operating...

All about Section 230: What It Does and Doesn't Say

09 Jun 2020

Contributed by Lukas

 We cover the tricky but important topic of Section 230 of the Communications Decency Act. The 1996 law has been in the headlines a lot recently, in ...

What We Can't Reveal We Can't Heal

04 Jun 2020

Contributed by Lukas

Given recent events around George Floyd and far beyond, this special episode of the a16z Podcast features Shaka Senghor, a leading advocate for crimi...

SaaS Go-to-Upmarket

29 May 2020

Contributed by Lukas

For a SaaS company, it's easier to move upmarket than down, and this gives SaaS startups the advantage against incumbents. In this episode,  David Ul...

New Fan Engagement Models for Athletes and Influencers

26 May 2020

Contributed by Lukas

Today’s episode is about a practical application of crypto — namely, the way it can “tokenize” fandom. More broadly, it’s about fan engageme...

Don't Call it a Brain in a Dish!

24 May 2020

Contributed by Lukas

Our understanding of the human brain and its disorders has always been limited by our lack of access to living, human, developing brain tissue. For th...

Pandemics: Early Detection, Networks, Spreaders

23 May 2020

Contributed by Lukas

Pandemics are predictable; what's not predictable is the intensity, or the precise timing of arrival. That's where early detection -- not just rapid w...

Podcasting and the Future of Audio

20 May 2020

Contributed by Lukas

This podcast (first recorded in 2019, now being rerun) -- is a podcast about podcasting: But it's really all about audio. A lot's changed... and a lot...

Growth in Turbulent Times

15 May 2020

Contributed by Lukas

 In normal times, every company operates against some hypothetical growth model—a data-driven framework that describes how your product grows and h...

Journal Club: Using CRISPR to Prevent Coronavirus and Influenza Infection

15 May 2020

Contributed by Lukas

In this episode of a16z bio Journal Club, general partner Vijay Pande, bio deal team partner Andy Tran, and bio editor Lauren Richardson discuss a nov...

What's Next in Gaming

07 May 2020

Contributed by Lukas

Video game technology has evolved into a global phenomenon that extends far beyond entertainment. In this episode, John Riccitiello, CEO of the game s...

Undruggable Drugs

06 May 2020

Contributed by Lukas

In this episode of the a16z Podcast, we take a deep dive into the world of drug development—specifically "undruggable drugs": a category of protein,...

The Next Generation of Cultural Influencers in Tech

02 May 2020

Contributed by Lukas

This episode—which originally took place as a live event—is a conversation between Seattle Seahawks linebacker Bobby Wagner and a16z Cultural Lead...

The Chief Security Officer in (and out of) a Crisis

29 Apr 2020

Contributed by Lukas

The Chief Security Officer (CSO/CISO) used to manage on-premise servers, now the information they have to secure has migrated to the cloud. As the res...

Journal Club: Finding New Antibiotics with Machine Learning, What Coronavirus Structures Tell Us

26 Apr 2020

Contributed by Lukas

a16z Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and wh...

Introducing Journal Club

26 Apr 2020

Contributed by Lukas

Announcing a16z Journal Club, a new show where we curate and discuss recent research papers with a16z experts and others. This new show continues the...

What the Narrow Waist of the Internet Means for Innovation Today

24 Apr 2020

Contributed by Lukas

Here is Ali's tweetstorm on the Narrow Waist of Blockchain Computing  Stay Updated:Find a16z on XFind a16z on LinkedInListen to the a16z Podcast on S...

IT'S TIME TO BUILD

21 Apr 2020

Contributed by Lukas

“It's Time to Build” by Marc Andreessen. You can also find and share this essay at a16z.com/build Stay Updated:Find a16z on XFind a16z on LinkedI...

Introducing Read Alouds

21 Apr 2020

Contributed by Lukas

We wanted to let you know about a special new series of posts occasionally read out loud from us  (you can learn more about the why and why now in ep...

The Passion Economy: Redefining Work

18 Apr 2020

Contributed by Lukas

This episode of the a16z Podcast covers the the rise of online platforms that enable people to make a living off their unique interests and skills. It...

When Bad Policy = Bad Business Models = Bad Public Health

16 Apr 2020

Contributed by Lukas

with @JorgeCondeBio, @julesyoo, and @omnivorousreadIn some ways, the coronavirus feels like it came out of nowhere—a kind of Black Swan event. But a...

Moving to Remote Development (and Work)

15 Apr 2020

Contributed by Lukas

From agile project management to asynchronous collaboration, development teams have pioneered many of the tools and best practices for remote work. Ho...

Virtual Oncology

10 Apr 2020

Contributed by Lukas

with @vintweeta @pbcancerdoc @sumitshahmd @omnivorousreadCoronavirus is now disrupting the entire health care system, not just because of the burden o...

The Story of Schizophrenia

07 Apr 2020

Contributed by Lukas

Descriptions of the mental illness we today call schizophrenia are as old as humankind itself. And more than likely, we are are all familiar with this...

Navigating the Numbers

04 Apr 2020

Contributed by Lukas

For any business, there are three core financial statements – the income or P&L statement, the balance sheet, and the cash flow statement. While the...

Gaming and Livestreaming: Connecting While Distancing

02 Apr 2020

Contributed by Lukas

Since social distancing measures were first put in place, time spent gaming has gone up—way up. According to a recent report by Verizon, video game ...

The Hustlers's Guide to Suing the Man

01 Apr 2020

Contributed by Lukas

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for p...

The Hustler's Guide to Elder Care

01 Apr 2020

Contributed by Lukas

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for p...

The Hustler's Guide to Nursing Jobs

30 Mar 2020

Contributed by Lukas

This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for p...

Hustlin' Tech, Round Two

30 Mar 2020

Contributed by Lukas

This is the next cycle of Hustlin' Tech -- a podcast series co-hosted by bestselling authors, a16z co-founder Ben Horowitz; and Shaka Senghor, a leadi...

Security When the Workforce Goes Remote

27 Mar 2020

Contributed by Lukas

We are in the midst of a rapid and unprecedented shift to remote work. What does it mean for security when the airgap between work and life is gone? H...

The Delivery-Optimized Future of Food

25 Mar 2020

Contributed by Lukas

The spike in online ordering and food delivery—a trend that's particularly relevant now—is evidence of how tech is fundamentally changing how and ...

Remote Work and Our New Reality

23 Mar 2020

Contributed by Lukas

Stay Updated:Find a16z on XFind a16z on LinkedInListen to the a16z Podcast on SpotifyListen to the a16z Podcast on Apple PodcastsFollow our host: http...

When Medicine Goes Virtual

19 Mar 2020

Contributed by Lukas

We’re at a moment where we are now seeing medicine go virtual faster, and at a scale that it has never done before. In this conversation,  a16z ...

Labs for Diagnostics: Then, Now, and Next

17 Mar 2020

Contributed by Lukas

A lot's going on in the world of healthcare right now, and one topic that's especially relevant is how diagnostic labs work. In this episode with Dave...

How a16z's Crypto Startup School Went Remote

14 Mar 2020

Contributed by Lukas

On February 21, Andreessen Horowitz kicked off its very first Crypto Startup School, with 45 students from around the U.S. and three countries gatheri...

When Fintech Meets Social

12 Mar 2020

Contributed by Lukas

The last financial crisis prompted many consumers to reassess their banking expectations—none more so than millennials and Gen-Z-ers. While revealin...

Innovation Through Software Development and IT

06 Mar 2020

Contributed by Lukas

One of the recurring themes we talk about a lot on the a16z Podcast is how software changes organizations, and vice versa... More broadly: it’s real...

The Open Source CIO

28 Feb 2020

Contributed by Lukas

In 2014, in "Why There Will Never Be Another Red Hat," Peter Levine argued that Red Hat’s open source business model of commercializing support and ...

Novel Coronavirus Updates: How Healthcare System, Tests Work; More

27 Feb 2020

Contributed by Lukas

This episode covers the following -- since our previous deep-dive on the novel coronavirus outbreak -- including:practical implications for the U.S. h...

Metrics and Mindsets for Retention & Engagement

20 Feb 2020

Contributed by Lukas

It's "Marketplaces Week" for us at a16z, thanks to our consumer team releasing a new index of the next industry-defining marketplaces, the Marketplace...

Tough Love, Global Diplomacy, and Lessons on Leadership

14 Feb 2020

Contributed by Lukas

Susan shares how she learned to leverage the characteristics of her personality early in her career as assistant secretary of state [2:05]One of the i...

Building the First CAR T Company

07 Feb 2020

Contributed by Lukas

with @OzAzamTmunity1, @JorgeCondeBio, and @omnivorousreadCAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer...

Rebel Talent

04 Feb 2020

Contributed by Lukas

When we think about rebellious behavior in the context of organizations and companies, we tend to think of rebels as trouble-makers, rabble-rousers; i...

All about the Coronavirus

30 Jan 2020

Contributed by Lukas

This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV...

The Truth about 1000 True Fans + Pricing Our Attention

27 Jan 2020

Contributed by Lukas

The idea of "1000 true fans" -- first proposed by Kevin Kelly in 2008 and later updated for Tools of Titans -- argued that to be a successful creator,...

Writers Writing, Readers Reading, Creators Creating

27 Jan 2020

Contributed by Lukas

We've been financing good writing with bad advertising -- and "attention monsters" (to quote Craig Mod) for way too long. So what happens when the tec...

What's Next for the Internet?

19 Jan 2020

Contributed by Lukas

How can we evolve the web for a better future? Has the web become a mature platform — or are we still in the early days of knowing what it can do an...

Controlling AI

16 Jan 2020

Contributed by Lukas

AI can do a lot of specific tasks as well as, or even better than, humans can — for example, it can more accurately classify images, more efficientl...

Food, Drugs, and Tech—100 Years of Public Health

14 Jan 2020

Contributed by Lukas

The federal agency known as the FDA, or the Food and Drug Administration, was born over 100 years ago—at the turn of the industrial revolution, in a...

On Pharma Trends and Big Company Innovation

11 Jan 2020

Contributed by Lukas

How does the world’s largest producer of medicines in terms of volume balance the science and the business of innovation? How does an enterprise at ...

Personal Genomics: Where Are We, Really?

06 Jan 2020

Contributed by Lukas

This is a turn of the decade (and January-themed) look backward/ look forward into personal genomics, given recent and past retrospective and prospect...

Why We Should Be Optimistic About the Future

02 Jan 2020

Contributed by Lukas

Many skeptics thought the internet would never reach mass adoption, but today it’s shaping global culture, is integral to our lives -- and it's just...

What to Know about CFIUS

23 Dec 2019

Contributed by Lukas

When innovation and capital go global, so do restrictions on trade, foreign investment, and more. Over the past couple years, U.S. policymakers have e...

Are ISAs the Solution to Student Debt?

19 Dec 2019

Contributed by Lukas

A bold proposal: You go to college for free, then pay back the school after graduation—but only if you get a job in your field of study and make a h...

Shonda Rhimes on How to Create Stories (and Products) People Want

17 Dec 2019

Contributed by Lukas

Hollywood and Silicon Valley seem so different, but are more alike than we think. What challenges do tech startup founders and other creative founders...

The Journey from 0 to 1, from Mosaic to Netscape

17 Dec 2019

Contributed by Lukas

As part of a new series where we will share select a16z partner appearances on other podcasts with our audience here, this episode is cross-posted fro...

Direct Listings, Myths and Facts

11 Dec 2019

Contributed by Lukas

We’ve covered a lot of the strategic financing milestones for startups seeking to build a sustainable and enduring business -- from mindsets for sta...

The Stories and Code of Culture Change

07 Dec 2019

Contributed by Lukas

There are some common tropes that can kill your company culture -- whether it's that corporate values can be weaponized; "fake it til you make it"; th...

Of Container Ships, Supply Chains, and Retail

03 Dec 2019

Contributed by Lukas

This podcast rerun -- first recorded over two and a half years ago, now being rerun as one of our evergreen classics on the tails of the world's large...

Nursing Today, From the Bedside and Beyond

28 Nov 2019

Contributed by Lukas

"Constant attention by a good nurse may be just as important as a major operation by a surgeon”, diplomat Dag Hammarskjöld once observed -- and tha...

How We Podcast

27 Nov 2019

Contributed by Lukas

"Hi everyone, welcome to the a16z Podcast..." ... and welcome to our 500th episode, where, for the first time, we reveal behind-the-scenes details and...

Brand Building Ideas… and People

20 Nov 2019

Contributed by Lukas

Many technical founders, academics, and other experts often believe that great products -- or great ideas! -- sell themselves, without any extra effor...

Come for the Games, Stay for the Party

02 Nov 2019

Contributed by Lukas

The games industry is in the midst of a tectonic shift. Powered by platform convergence, games-as-a-service, and user-generated content, modern video ...

AI in B2B

24 Oct 2019

Contributed by Lukas

Consumer software may have adopted and incorporated AI ahead of enterprise software, where the data is more proprietary, and the market is a few thous...

Free Software and Open Source Business

21 Oct 2019

Contributed by Lukas

Today, despite the critical importance of open source to software, it’s still seen by some as blasphemous to make money as an open source business. ...

Of Emojis and Innovation

15 Oct 2019

Contributed by Lukas

This rerun podcast (first recorded in 2015, now being rerun as one of our evergreen classics/ favorites) -- is ALL about emoji. But it's really about ...

The Environment, Capitalism, Technology

04 Oct 2019

Contributed by Lukas

It used to be that the only way for humanity to grow -- and progress -- was through destroying the environment. Sure, the Industrial Revolution brough...

16 Minutes on the News #10: Amazon Healthcare, Oculus VR/AR, Google Quantum Supremacy?

30 Sep 2019

Contributed by Lukas

Our news podcast, 16 Minutes -- where we quickly cover the top headlines of the week, the a16z way (why are these topics in the news; what's real, wha...

New Business Models for Gaming, Collaboration, Creativity

28 Sep 2019

Contributed by Lukas

The combination of cloud, social, and mobile took gaming beyond a small base of just console- and PC-gamers to a massive player base. But the underlyi...

16 Minutes on the News #9: All the Recent Phone Hacks

23 Sep 2019

Contributed by Lukas

This is episode #9 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they’re in the news; why t...

a16z Podcast: The Biology of Pain

17 Sep 2019

Contributed by Lukas

What is the nature of physical pain? Why do we even experience it? Is there one type, or many? Do people experience pain differently? What is happenin...

16 Minutes on the News #8: Apple Camera, Services; Wearables - Where are We

16 Sep 2019

Contributed by Lukas

with @benedictevans @vijaypande and @smc90 This is episode #8 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a...

a16z Podcast: How to Pay for Healthcare Based on Health

06 Sep 2019

Contributed by Lukas

There's been a lot of talk about the need for our healthcare system to shift away from volume and fee-for-service, where you pay by appointment, proce...

The Hustler's Guide to the Hair Business

06 Sep 2019

Contributed by Lukas

with @bhorowitz @shakasenghor @diishanimira @therealritabee Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology pl...

The Hustler's Guide to Getting Paid

06 Sep 2019

Contributed by Lukas

with @bhorowitz @shakasenghor ram @earnin & vaughn ferguson Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technolo...

The Hustler's Guide to Preschool

06 Sep 2019

Contributed by Lukas

with @bhorowitz @shakasenghor @8ennett & sherie james Hustlin’ Tech is a new show (part of the a16z Podcast) that introduces the technology plat...

Introducing Hustlin' Tech

06 Sep 2019

Contributed by Lukas

We're excited to introduce a new podcast series hosted by a16z co-founder Ben Horowitz and Shaka Senghor, a leading voice in criminal justice reform a...

a16z Podcast: Making Culture, Making Influence -- Dapper Dan!

02 Sep 2019

Contributed by Lukas

"You cannot be IN it... and not be OF it." Dapper Dan a.k.a. Daniel Day shares his remarkable history and story of defining an era of fashio...

a16z Podcast: From the Internet's Past to the Future of Crypto

29 Aug 2019

Contributed by Lukas

What can we learn from the history of the internet for the future of crypto? In this episode of the a16z Podcast, general partner Katie Haun interview...